ArticleBrain and behavior2025
Identifying Druggable Inflammatory Proteins Causally Contributing to Parkinson's Disease.
Article in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Identifying Druggable Inflammatory Proteins Causally Contributing to Parkinson's Disease.Brain and behavior · 2025Article
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Authors and funding
4 authors.
Funding
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Abstract
backgroundInflammatory mechanisms are critically engaged in the pathogenesis of Parkinson's disease (PD). The objective of this research was to detect circulating inflammatory proteins that potentially elevate the susceptibility to PD.
methodsA two-sample Mendelian randomization (MR) analysis was performed to determine the causal effects of 91 circulating inflammatory proteins (14,824 participants) on PD (33,674 cases and 449,056 controls) by using genome-wide association study (GWAS) summary data. The MR analysis utilized three complementary approaches: inverse variance weighted (IVW), weighted median, and MR-Egger. Among them, IVW was the principal method. Additionally, we utilized the Drug-Gene Interaction Database (DGIdb) to select potential therapeutic targets for proteins associated with PD.
resultsOur MR analysis revealed that six circulating inflammatory proteins were associated with PD. Three of them conferred a protective effect against PD, including TNFRSF9 (odds ratio [OR]: 0.83, 95% confidence interval [CI]: 0.74-0.92, p = 5.09 × 10
conclusionOur research revealed the pathogenic contribution of several inflammatory proteins to PD development, providing new perspectives on the mechanisms and therapy of PD.
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