SynthesisBrain and behavior2025
Prevalences of Anorexia, Autism, and Schizophrenia, Are Strongly Associated With Average Annual Temperatures: Systematic Review and Linear Regression Analysis.
Synthesis in Brain and behavior, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prevalences of Anorexia, Autism, and Schizophrenia, Are Strongly Associated With Average Annual Temperatures: Systematic Review and Linear Regression Analysis.Brain and behavior · 2025Pooled it
- The role of nitrogen dioxide in the prevalence of adverse cardiovascular and cerebrovascular diseases in China: a national multi-pollutant geospatial analysis.BMC public health · 2026Article
- Prenatal exposure to extreme heat and autism in children.The Science of the total environment · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe impact of potential environmental influences, like temperature changes and latitudinal gradient, has not been investigated in depth in psychiatric diseases. The aim of this project was to investigate the association of geographical latitude and temperature with the prevalence of psychiatric disorders.
methodsLinear regression analysis was performed for 201 countries by analyzing average annual temperatures and age-standardized rates (prevalence) of seven major psychiatric entities. A systematic review was also performed, investigating if these correlation data were supported by published original studies.
resultsLinear regression analysis showed a significant correlation between average annual temperatures and age-standardized rates (p < 0.0001) for three psychiatric disorders: anorexia, autism, and schizophrenia. Systematic review analysis showed that the prevalence of autism and schizophrenia is potentially influenced by geographic and climatic factors. However, no published data were identified to support the findings for anorexia.
conclusionThese preliminary findings underscore the complexity of interactions between environmental, genetic, and socioeconomic factors for psychiatric diseases. The association between temperature and prevalence of psychiatric diseases needs further investigation to reveal any unknown epidemiological factors that contribute to disease pathogenesis.
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Registered trials
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