Evidence map›Paper›PMID 41116321›Full record

ArticleAdvanced healthcare materials2026

Photoactivated Proximity Protein Labeling Reveals Enhanced Tumor Retention of a D-Peptide-Ruthenium Prodrug Conjugate.

Liyan Zhang, Peiyuan Wang, Hildert Bronkhorst, Yurii Husiev, Ludovic Bretin, Maarten N van Ginkel, Wen Sun, Sylvestre Bonnet

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced healthcare materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Liyan ZhangLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, Leiden, 2333 CC, Netherlands.
Peiyuan WangState Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian, 116024, P. R. China.
Hildert BronkhorstLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, Leiden, 2333 CC, Netherlands.
Yurii HusievLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, Leiden, 2333 CC, Netherlands.
Ludovic BretinLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, Leiden, 2333 CC, Netherlands.
Maarten N van GinkelLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, Leiden, 2333 CC, Netherlands.
Wen SunState Key Laboratory of Fine Chemicals, Dalian University of Technology, 2 Linggong Road, Dalian, 116024, P. R. China.
Sylvestre BonnetLeiden Institute of Chemistry, Universiteit Leiden, Einsteinweg 55, Leiden, 2333 CC, Netherlands.ORCID 0000-0002-5810-3657

Funding

China Scholarship Council 201806450039Nederlandse Organisatie voor Wetenschappelijk Onderzoek VI.C.182.011
6 · The paper itself

Abstract

Amino acid chirality is known to influence the biological properties of peptide-containing prodrugs. In this work, both Δ and Λ isomers of three cyclic ruthenium-peptide photoactivated chemotherapy (PACT) conjugates [1]Cl

Indexed as

Antineoplastic AgentsPeptidesProdrugsRutheniumA549 CellsAnimalsHumansLung NeoplasmsMiceMice, NudeXenograft Model Antitumor AssaysAntineoplastic AgentsPeptidesProdrugsRutheniumpeptide chiralityphotoactivated chemotherapyproximity protein labelingruthenium‐peptide conjugates

Identifiers

PMID41116321
PMCPMC12864594

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.