ReviewMini reviews in medicinal chemistry2025
Synthesis and Biological Properties of Isatin-indole Hybrids: A Review.
Review in Mini reviews in medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Facile Chemodivergent Synthesis of Fused Indolo[2,3‑ACS omega · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIsatin (1H-indole-2,3-dione) and indole are versatile scaffolds with diverse pharmacological activities, including antimicrobial, anticancer, antiviral, anticonvulsant, antiinflammatory, and analgesic effects. Isatin-indole hybrids have emerged as multifunctional agents with significant potential in drug discovery.
methodsA literature survey (2010-2025) across major databases (PubMed, Google Scholar, ACS, etc.) included reports on synthesis, biological evaluation, and structure-activity relationship (SAR) analysis.
resultsNumerous synthetic approaches, including both conventional and green methods, have yielded a diverse range of isatin-indole derivatives. Many exhibited potent antimicrobial, anticancer, antioxidant, and antitubercular activities, with SAR studies highlighting the impact of substitution patterns on activity and selectivity. DISCUSSION: This review aims to provide a comprehensive overview of hybrid molecules in which the isatin core is covalently linked to an indole scaffold. It focuses on their synthesis, diverse biological activities and structure-activity relationship (SAR) studies from 2001 onwards.
conclusionThis review provides a concise summary of the latest developments and future outlook for the therapeutic potential of isatin-indole hybrids in the development of potent bioactive drugs.
Indexed as
Identifiers
41116269What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.