Evidence map›Paper›PMID 41116192›Full record

ArticleACS infectious diseases2025

Development of Pyrimido Pyridazine Analogs through Increased Whole Cell Target Engagement of the Dihydropteroate Synthase Pterin Binding Site in Gram-Negative Bacteria.

Hannah E Snoke, Stephanie M Reeve, Suresh Dharuman, Miranda J Wallace, Victoria C Loudon, Ying Zhao, John J Bowling, Patricia A Murphy, Brett Waddell, Robin B Lee and 2 more

Abstract read
In one paragraph

Article in ACS infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Hannah E SnokeDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.
Stephanie M ReeveDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.
Suresh DharumanDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.
Miranda J WallaceDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.
Victoria C LoudonDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.
Ying ZhaoDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.
John J BowlingDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.
Patricia A MurphyDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.
Brett WaddellDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.
Robin B LeeDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.
Jürgen B BulittaUniversity of Florida College of Pharmacy - Lake Nona Campus, 6550 Sanger Road, Orlando, Florida 32827, United States.ORCID 0000-0001-7352-3097
Richard E LeeDepartment of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38103, United States.ORCID 0000-0002-2397-0443

Funding

Translational development of new agents alone and in combination to combat Gram-negative pathogens important in Ventilator- Associated Bacterial Pneumonia: Leveraging the Gram-negative toolbox that isP01AI179409 · NIAID · UNIVERSITY OF FLORIDA · PI Ashley Brown, Jurgen Bernd Bulitta · 2024 to 2026
$9.3M
Combating resistant superbugs by understanding the molecular determinants of target site penetration and bindingR01AI136803 · NIAID · UNIVERSITY OF FLORIDA · PI BULITTA, JURGEN BERND · 2018 to 2022
$5.7M
NIAID NIH HHS P01 AI179409NIAID NIH HHS R01 AI136803
6 · The paper itself

Abstract

Dihydropteroate synthase (DHPS) is a critical enzyme in the folate biosynthetic pathway of bacteria, fungi, and protozoans. Sulfonamides successfully target the

Indexed as

Anti-Bacterial AgentsDihydropteroate SynthaseEnzyme InhibitorsGram-Negative BacteriaPterinsPyridazinesPyrimidinesBinding SitesEscherichia coliMicrobial Sensitivity TestsAnti-Bacterial AgentsDihydropteroate SynthaseEnzyme InhibitorsPterinsPyridazinesPyrimidinesantifolatesGram-negative bacteriaGram-negative permeabilitytarget engagement

Identifiers

PMID41116192
PMCPMC12624742

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.