Evidence map›Paper›PMID 41116190›Full record

ArticleGenome medicine2025

HLA-DRB1*15:01 is associated with a reduced likelihood of longevity in northern European men.

Nicolás Mendoza-Mejía, Daniel Kolbe, Onur Özer, Janina Dose, Guillermo G Torres, Andre Franke, Marianne Nygaard, Almut Nebel

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genome medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicolás Mendoza-MejíaInstitute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Daniel KolbeInstitute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Onur ÖzerInstitute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Janina DoseInstitute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Guillermo G TorresInstitute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Andre FrankeInstitute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany.
Marianne NygaardEpidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark.
Almut NebelInstitute of Clinical Molecular Biology, Kiel University, University Hospital Schleswig-Holstein, Kiel, Germany. a.nebel@mucosa.de.

Funding

Deutsche Forschungsgemeinschaft 390884018Deutsche Forschungsgemeinschaft 400993799
6 · The paper itself

Abstract

backgroundPrior research on the genetics of human longevity has identified only a few robust associations. While these studies highlight the importance of metabolic processes for longevity, the contribution of immune genes, specifically those in the highly polymorphic human leukocyte antigen (HLA) region, remains understudied. Here, we addressed this gap by analysing the influence of HLA variation on longevity in Europeans.

methodsWe conducted an initial case-control study, comparing imputed HLA alleles from a German longevity cohort with younger controls. Associations were evaluated with logistic regression, adjusting for multiple testing and population structure. Subsequently, significant associations (adjusted P ≤ 0.05) were tested for replication in two additional populations of similar ancestry: a Danish longevity cohort and the UK Biobank. Furthermore, epitope binding and immunogenicity predictions were performed to detect potential mechanisms linking HLA alleles to longevity.

resultsOur analysis revealed a novel male-specific association of HLA-DRB1*15:01:01 with longevity (adjusted P = 2.80 × 10

conclusionsThe novel male-specific association between HLA-DRB1*15:01 and longevity has been observed in three independent cohorts. The anti-longevity effect of this association is perhaps a consequence of an increase in Alzheimer's disease (AD)-related mortality in men carrying this allele. This hypothesis is based on prior research that has identified a male-specific association between HLA-DRB1*15:01:01 and AD. Additionally, it is likely that this link is mediated by increased immune reactivity against APOB-100, which is promoted by HLA-DRB1*15:01:01.

Indexed as

HLA-DRB1 ChainsLongevityWhite PeopleAgedAged, 80 and overAllelesCase-Control StudiesFemaleGene FrequencyHumansMaleMiddle AgedPolymorphism, Single NucleotideHLA-DRB1*15:01 antigenHLA-DRB1 ChainsAgeingGenetic association studyHuman leukocyte antigenImmunogeneticsLongevity

Identifiers

PMID41116190
PMCPMC12539080

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.