ArticleBMC medicine2025
Human platelet-derived extracellular vesicle fractions modulate bone cell metabolism and biologize volume-stable β-TCP matrix in vitro.
Article in BMC medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Effects of extended guided bone regeneration on the labial alveolar wall of adjacent teeth in the anterior maxilla: a retrospective cohort study.Head & face medicine · 2026Article
- Exercise stress and tissue remodeling: advances in exosome-mediated RNA-RBP networks in musculoskeletal injury repair and functional recovery.Frontiers in genetics · 2026Review
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Authors and funding
5 authors.
Funding
Abstract
backgroundBone regenerative medicine focuses on restoring damaged tissue, with bone augmentation materials commonly used to fill defects, support recovery and addressing issues related to aging, bone diseases or trauma in dental and orthopedic procedures. To avoid complications associated with harvesting autogenous tissue grafts, novel applications focus on alloplastic materials to support regenerative and healing processes. However, current synthetic materials demonstrate shortcomings specifically pertaining to mimicking bone regenerative properties of autogenous bone. Whether bioactive fractions enriched for human platelet lysate derived extracellular vesicles (hPLEV-Fs) could biologize alloplastic materials with their non-immunogenic tissue-restorative potential, stimulate intercellular communication between bone-forming osteoblasts and bone-resorbing osteoclasts and transform alloplastic materials in potent regenerative grafts needs to be determined.
methodsThis study investigated hPLEV-Fs impact on bone regenerative pathways and evaluated whether combination with a collagen-embedded β-tricalcium phosphate (β-TCP) three-dimensional matrix enhances bone regeneration.
resultsTreatment with hPLEV-F improved osteoblasts' proliferation, differentiation and mineralization in both murine and human primary osteoblasts while reducing inflammatory responses, which was further supported by systems-wide phosphoproteome-screening of bone-remodeling pathways. Although initial pre-osteoclastic differentiation was enhanced under hPLEV-F treatment, cells remained in a non-resorbing state, indicating potential for increased net bone formation. Furthermore, hPLEV-F stimulated osteoblasts to increase osteoprotegerin secretion, limiting osteoclast differentiation, especially in combination with β-TCP biomaterial.
conclusionsOur data demonstrate the potential of hPLEV-F to stimulate bone cell interaction and support bone regenerative pathways, thereby suggesting it as a biologizing agent in combination with synthetic biomaterial. This creates innovative possibilities in biointerface engineering thereby advancing patient care in clinical applications.
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