Evidence map›Paper›PMID 41116115›Full record

ArticleNature neuroscience2025

A lateral hypothalamic neuronal population expressing leptin receptors counteracts anxiety to enable adaptive behavioral responses.

Rebecca Figge-Schlensok, Anne Petzold, Nele Hugger, Alisa Bakhareva, Ali Taleb Abdallah, Chantal Wissing, Hanna Elin van den Munkhof, Marla Yasmin Witt, Deema Imad Awad, Tatiana Korotkova

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Hypothalamic control of arousal.Reviews in endocrine & metabolic disorders · 2026
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Rebecca Figge-Schlensok *Institute for Systems Physiology, Faculty of Medicine, University of Cologne/University Clinic Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0003-4141-5598
Anne Petzold *Institute for Systems Physiology, Faculty of Medicine, University of Cologne/University Clinic Cologne, Cologne, Germany. a.petzold@eni-g.de.ORCID http://orcid.org/0000-0003-3558-9014
Nele HuggerInstitute for Systems Physiology, Faculty of Medicine, University of Cologne/University Clinic Cologne, Cologne, Germany.ORCID http://orcid.org/0009-0006-1980-4991
Alisa BakharevaInstitute for Systems Physiology, Faculty of Medicine, University of Cologne/University Clinic Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-9292-8508
Ali Taleb AbdallahCluster of Excellence Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0002-8768-3232
Chantal WissingInstitute for Systems Physiology, Faculty of Medicine, University of Cologne/University Clinic Cologne, Cologne, Germany.
Hanna Elin van den MunkhofInstitute for Systems Physiology, Faculty of Medicine, University of Cologne/University Clinic Cologne, Cologne, Germany.ORCID http://orcid.org/0000-0001-9770-9099
Marla Yasmin WittInstitute for Systems Physiology, Faculty of Medicine, University of Cologne/University Clinic Cologne, Cologne, Germany.ORCID http://orcid.org/0009-0003-7600-8439
Deema Imad AwadInstitute for Systems Physiology, Faculty of Medicine, University of Cologne/University Clinic Cologne, Cologne, Germany.
Tatiana KorotkovaInstitute for Systems Physiology, Faculty of Medicine, University of Cologne/University Clinic Cologne, Cologne, Germany. tatiana.korotkova@uk-koeln.de.ORCID http://orcid.org/0000-0001-7964-9838

Funding

Deutsche Forschungsgemeinschaft (German Research Foundation) 233886668-GRK1960Deutsche Forschungsgemeinschaft (German Research Foundation) 431549029 - SFB 1451Deutsche Forschungsgemeinschaft (German Research Foundation) EXC 2030 - 390661388Deutsche Forschungsgemeinschaft (German Research Foundation) EXC2030 CECAD
6 · The paper itself

Abstract

Neuronal mechanisms that facilitate adaptive strategies to enable an animal to overcome anxiety in threatening situations remain unknown. Using single-cell calcium imaging and cell-type-specific activity manipulations in behaving mice, we identified leptin-sensitive neuronal subpopulations in the lateral hypothalamus (LH; LepR

Indexed as

Adaptation, PsychologicalAnxietyHypothalamic Area, LateralNeuronsReceptors, LeptinAnimalsAnorexia NervosaBehavior, AnimalFemaleLeptinMaleMiceMice, Inbred C57BLMice, TransgenicPrefrontal CortexLeptinReceptors, Leptin

Identifiers

PMID41116115
PMCPMC12586148

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.