ReviewLasers in medical science2025
From reactive oxygen to cancer cell death: the science behind photodynamic therapy.
Review in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Mechanism-guided design of specific-activated photosensitizers for precision photodynamic therapy.Chemical science · 2026Review
- Current Perspectives on Photodynamic Therapy for Skin Diseases: A Narrative Review.Clinical, cosmetic and investigational dermatology · 2026Review
- Fluorescence-guided surgery combined with intraoperative photodynamic therapy for recurrent atypical and anaplastic intracranial meningiomas: a prospective feasibility study.Frontiers in oncology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic therapy (PDT) is an innovative and minimally invasive approach that has attracted considerable attention and interest in the medical community in recent years. The technique is primarily used to treat tumors and has received official approval for the management of several types of cancer. The process involves the injection of specialized light-sensitive materials into the body. Subsequently, when light of an optimal wavelength (the wavelength at which the photosensitizer is best absorbed and penetrates the tissue) is directed at these materials, it causes the production of reactive oxygen species. These reactive oxygen species play an important role in inducing cellular damage that ultimately leads to the death of cancer cells. Therefore, this treatment modality is based on three fundamental principles. This review comprehensively examines the fundamental principles governing PDT, with a specific focus on photosensitizer design, irradiation parameters, and tumor microenvironment oxygenation. A critical analysis of each component is provided, underscoring their collective importance in optimizing PDT efficacy for oncological applications.
Indexed as
Identifiers
41116088What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.