In one paragraphArticle in EMBO reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Wenqi Dong *College of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, China.ORCID 0009-0001-5226-648X Licheng Yuan *College of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, China.ORCID 0000-0002-9598-2283 Jiangming Shang *Department of Biophysics and Disease Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.ORCID 0009-0009-6023-3512 Fan YangDepartment of Biophysics and Disease Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.ORCID 0000-0002-0520-5254 Shilong YangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, China.ORCID 0000-0002-2618-1837 Xiancui LuCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, China.ORCID 0000-0002-9539-852X Qian WangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, China.
Anna LuoCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, China.
Jiheng GengCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, China.
Jiatong ChengCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, China.
Runze LiCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, China.
Yunfei WangCollege of Wildlife and Protected Area, Northeast Forestry University, Harbin, Heilongjiang, China. wangyunfei@nefu.edu.cn.ORCID 0000-0001-7693-0595 Funding
Fundamental Research Funds for the Central Universities 2572023CT13Fundamental Research Funds for the Central Universities 2572025JT07Longjiang Science and Technology Talents Spring Goose Support Program CYQN24058MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 2572022DS03MOE | Fundamental Research Funds for the Central Universities (Fundamental Research Fund for the Central Universities) 2572025AW13MOST | National Key Research and Development Program of China (NKPs) 2023YFF1304900MOST | National Key Research and Development Program of China (NKPs) 2023YFF1305000MOST | National Natural Science Foundation of China (NSFC) 32170486MOST | National Natural Science Foundation of China (NSFC) 32370437MOST | National Natural Science Foundation of China (NSFC) 32370505MOST | National Natural Science Foundation of China (NSFC) 32430012National Key Research and Development Program of Heilongjiang province 2024ZXDXC28National Natural Science Foundation of Heilongjiang Province YQ2022H001
6 · The paper itselfAbstract
Acid sensing is essential for various biological processes in animals, yet it exhibits species-specific characteristics. In this study, we identified a proton-dissociation-permeated sodium channel (PDPNaC1) in the antennal sensory neurons of the centipede Scolopendra subspinipes mutilans. PDPNaC1, which is permeable to monovalent cations, assembles as a homotrimer. Unlike most proton-gated channels, where proton binding induces currents, PDPNaC1's transient ion-permeable state is triggered by proton dissociation. By resolving the high-resolution cryo-electron microscopy (cryo-EM) structure of PDPNaC1, combined with mutagenesis and electrophysiological analyses, we identified Gly378, rather than the Gly-Ala-Ser tract, as a key determinant of ion selectivity. Furthermore, Ser376, located in the ion-permeable pathway, likely serves as a proton-binding site, leading to an H
Indexed as
ArthropodsIon Channel GatingProtonsSodium ChannelsAnimalsBinding SitesCryoelectron MicroscopyModels, MolecularSensory Receptor CellsProtonsSodium ChannelsAcid-sensingAntennal Sensory NeuronsCryo-electron MicroscopyPDPNaC1Proton-gated Channel
Identifiers
PMID41116071
PMCPMC12714832
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