ArticleNature structural & molecular biology2025
Global analysis of translocon remodeling during protein synthesis at the ER.
Article in Nature structural & molecular biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Cotranslational membrane protein biogenesis by an EMC-bound translocon.Nature structural & molecular biology · 2026Article
- Pairwise transmembrane domain insertion during multipass protein biogenesis.Molecular cell · 2026Article
- Design principles of human membrane protein topology.The Journal of cell biology · 2026Article
- Substrate-induced assembly and functional mechanism of the membrane protein insertase SecYEG-YidC.The EMBO journal · 2026Article
- Membrane Protein Insertion in Cells: Principles, Pathways, and Quality Control.Chemical reviews · 2026Review
- SARS-CoV-2 membrane protein biogenesis.bioRxiv : the preprint server for biology · 2026Article
- The ER membrane protein complex acts as a chaperone to promote the biogenesis of multi-bundle membrane proteins.bioRxiv : the preprint server for biology · 2026Article
- Article
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Authors and funding
9 authors.
Funding
Abstract
Protein biogenesis at the endoplasmic reticulum requires translocons comprising the Sec61 protein-conducting channel and several dynamically associated accessory factors. Here we used transcriptome-wide selective ribosome profiling in human cells to monitor cotranslational interactions of accessory factors for N-glycosylation (the OST-A complex) and multipass membrane protein synthesis (the GEL, PAT and BOS complexes). OST-A was preferentially recruited to open Sec61 channels engaged in polypeptide translocation; conversely, GEL, PAT and BOS were recruited synchronously to closed Sec61 channels and stabilized by newly inserted transmembrane domains. Translocon composition changed repeatedly and reversibly during the synthesis of topologically complex multipass membrane proteins. These data establish the molecular logic that underlies substrate-driven translocon remodeling, events that are crucial for the efficient biogenesis of secretory and membrane proteins.
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Registered trials
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