Evidence map›Paper›PMID 41115999›Full record

ArticleJournal of cancer survivorship : research and practice2025

Long-term quality of life in head and neck cancer: the role of postdiagnosis smoking behavior.

Elham Mohebbi, Alaina L Carr, Garret Guthrie, Siddhi Patil, Emily Clementi, Jonathan Giurintano, Matthew Witek, Ming Tan, Ruzong Fan, Steven Chinn and 4 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of cancer survivorship : research and practice, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Elham MohebbiDepartment of Oncology, School of Medicine, Georgetown University, Washington, DC, USA.
Alaina L CarrDepartment of Oncology, School of Medicine, Georgetown University, Washington, DC, USA.
Garret GuthrieDepartment of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Medical Center, Washington, DC, USA.
Siddhi PatilDepartment of Oncology, School of Medicine, Georgetown University, Washington, DC, USA.
Emily ClementiSchool of Medicine, Georgetown University, Washington, DC, USA.
Jonathan GiurintanoDepartment of Otolaryngology, MedStar Georgetown University Hospital, Washington, DC, USA.
Matthew WitekDepartment of Otolaryngology, MedStar Georgetown University Hospital, Washington, DC, USA.
Ming TanDepartment of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Medical Center, Washington, DC, USA.
Ruzong FanDepartment of Biostatistics, Bioinformatics and Biomathematics, Georgetown University Medical Center, Washington, DC, USA.
Steven ChinnDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Gregory WolfDepartment of Otolaryngology-Head and Neck Surgery, University of Michigan, Ann Arbor, MI, USA.
Kristi D GravesDepartment of Oncology, School of Medicine, Georgetown University, Washington, DC, USA.
Peter H AhnDepartment of Radiation Medicine, MedStar Georgetown University Hospital, Washington, DC, USA.
Laura RozekDepartment of Oncology, School of Medicine, Georgetown University, Washington, DC, USA. lr898@georgetown.edu.

Funding

Therapeutic Potential and Mechanism of Action of Potent Small Molecule InhibitorsP50CA097248 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NOR, JACQUES EDUARDO · 2002 to 2013
$25.3M
NCI NIH HHS 2P50CA097248-06A1NCI NIH HHS P50 CA097248
6 · The paper itself

Abstract

purposeHead and neck squamous cell carcinoma (HNSCC) significantly impacts patients' quality of life (QoL). This study investigated long-term QoL outcomes among 619 patients with newly diagnosed HNSCC over five years.

methodsQoL was assessed annually using the SF-36, covering physical functioning, emotional well-being, social functioning, pain, and general health. Patients were stratified by tumor subsite and smoking status.

resultsSignificant improvements in QoL were observed at the 1-year follow-up, particularly among patients with pharyngeal [adjusted β: 3.56 (95% CI: 1.69, 5.43)] and oral cavity cancers [adjusted β: 2.56 (95% CI: 0.52, 4.60)]. However, patients with laryngeal cancer showed no significant change at any follow-up [e.g., 1-year adjusted β: 0.93 (95% CI: -2.36, 4.24)]. Overall, QoL improved most notably in the early years post-treatment [adjusted β: 2.86 (95% CI: 1.56, 4.16)]. Smoking status significantly influenced QoL trajectories. Never-smokers showed the greatest improvement (from 53.11 at baseline to 59.29 at year 2, P < 0.0001), followed by quitters (48.09 to 51.42, P = 0.04). Continued and intermittent smokers demonstrated no significant gains.

conclusionsIn this longitudinal study of HNSCC patients, quality of life significantly improved over time, particularly among those with pharyngeal and oral cavity tumors and those who never smoked or quit smoking after diagnosis. IMPLICATIONS FOR CANCER SURVIVORS: These findings highlight the importance of smoking cessation in survivorship care. Personalized care strategies addressing both physical and psychosocial challenges, particularly for continued smokers and those with laryngeal tumors, are essential to improving long-term QoL in HNSCC survivors.

Indexed as

Head and neck neoplasmsMouth neoplasmsPsychological well-beingQuality of lifeSF-36Smoking cessation

Identifiers

PMID41115999

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.