Integrated Experimental and Computational Investigation of Flavonoid-Nile Blue Interactions: Binding Mechanism, Antioxidant Activity, and PLS Modeling.

C Manivannan, Sambath Baskaran, Thayalaraj Christopher Jeyakumar, P Pachamuthu, R Renganathan

Abstract read

In one paragraph

Article in Journal of fluorescence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

5 authors.

C ManivannanDivision of Chemistry, School of Sciences, SRM Institute of Science and Technology, Tiruchirappalli, Tamilnadu, 621105, India. cmanivannan89@gmail.com.

Sambath BaskaranDepartment of Chemistry, Saveetha Engineering College, Chennai, 602105, Tamil Nadu, India.

Thayalaraj Christopher JeyakumarDepartment of Chemistry, The American College, Tallakkulam, Madurai, 625025, Tamil Nadu, India.

P PachamuthuDivision of Chemistry, School of Sciences, SRM Institute of Science and Technology, Tiruchirappalli, Tamilnadu, 621105, India.

R RenganathanSchool of Chemistry, Bharathidasan university, Tiruchirappalli, Tamil Nadu, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Flavonoids are naturally occurring antioxidants with a variety of biological activity. Fluorescence techniques can be used to investigate their molecular interactions. Using a combination of computational and experimental methods, we examined the photoinduced interaction between a number of structurally different flavonoids and the cationic fluorescent dye Nile Blue (NB) in this work. Flavonoid-induced dampening of NB emission and ground-state complex formation were validated by steady-state fluorescence studies and UV-visible absorption. The efficiency of the quenching was better in polar protic media and under basic circumstances, and it was reliant on both pH and solvent. Studies of time-resolved fluorescence revealed a static quenching mechanism, which was corroborated by spectrum shifts and thermodynamic characteristics. Bimolecular quenching rate constants (k

Indexed as

AntioxidantsFlavonoidsOxazinesDensity Functional TheoryLeast-Squares AnalysisMolecular StructureSpectrometry, FluorescenceThermodynamicsAntioxidantsFlavonoidsNile BlueOxazinesAntioxidantsFlavonoidsFluorescence quenchingNile bluePartial linear square analysis

Identifiers

PMID41115991

DOI10.1007/s10895-025-04550-1

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.