Effects on chemotherapy-induced peripheral neuropathy by moderate strength training in combination with whole-body vibration in breast cancer patients.

purposeThis study aimed to evaluate the effects of a 12-week programme, including moderate strength training with and without whole-body vibration (WBV), on chemotherapy-induced peripheral neuropathy (CIPN) associated symptoms in breast cancer patients undergoing paclitaxel-containing therapy. The goal was to assess the effects on sensory, motor, and autonomic symptoms and on balance, depth sensitivity, and the vibration sensation.

methodsIn this randomized controlled trial, 66 patients were allocated to one of three groups: (i) strength training only (SG), (ii) strength training with WBV (VG), and (iii) a control group (CG) with standard activity advices. Supervised training sessions occurred twice a week during chemotherapy. Outcomes, including balance (Fullerton Advanced Balance Scale, Berg Balance Scale), vibration sensation (tuning fork test), and CIPN symptoms (EORTC QLQ-CIPN20), were assessed at baseline (T0), 6 weeks (T1), and 12 weeks (T2).

resultsNo adverse events were recorded, and adherence was high (68.18%). Positive trends indicated stabilized vibration sensation in the SG and VG compared to the control group, but no significant differences were observed. Vibration perception decreased less in the intervention groups, and motor symptoms worsened only in the control group. Balance remained stable across all groups.

conclusionBoth strength training alone and combined with WBV are feasible and safe during chemotherapy. Although WBV did not provide additional benefits over strength training alone, both interventions showed potential protective effects against CIPN symptoms. IMPLICATIONS FOR CANCER SURVIVORS: Moderate strength training, with or without WBV, may help prevent or alleviate CIPN symptoms, supporting better physical function during chemotherapy. Early implementation of such programmes could reduce treatment-related side effects.