SynthesisPsychopharmacology2026
Stress and alcohol impact network states involved in emotional processing: relevance of comorbid AUD and psychiatric illnesses.
Synthesis in Psychopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Targeting PAI-1 with TM5441 Mitigates Chronic Social Stress-Induced Anxiety-Like Behavior and Stress-Induced Increases in Ethanol Intake and Preference.Neurochemical research · 2026Article
- Driving in emergency medical service settings: a cross-sectional study of clinical psychological factors and perceived stress in a sample of ambulance drivers.Frontiers in public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
rationaleThe complex relationship between stress and alcohol involves bidirectional influences in which stress impacts alcohol intake and alcohol exposure and withdrawal contribute to stress. Similar brain regions have been implicated in mediating the effects of alcohol and stress and accumulating evidence points to altered network states in contributing to psychiatric illnesses and alcohol use disorder.
objectivesThis review explores the overlapping brain networks mediating the effects of stress and alcohol and the role they play in alcohol use disorder and stress-related disorders.
methodsWe performed a systematic review and meta-analysis on empirical studies assessing the impact of acute alcohol and acute stress exposure on resting network states, functional and electrographic network states, and alterations associated with AUD and stress-related disorders. We performed a network analysis to extract and visualize the brain regions involved in acute alcohol exposure, the effects of acute stress, alcohol use disorder, and stress-related disorders.
resultsThis systematic review and meta-analyses demonstrate that alcohol and stress impact the activity of similar brain regions, particularly those which serve as key nodes involved in emotional processing. Further, we demonstrate alterations in these networks associated with alcohol use disorder and stress-related disorders, such as major depressive disorder, anxiety disorders, and posttraumatic stress disorder.
conclusionsOur meta-analysis shows similar networks which are influenced by stress and alcohol, which may contribute to their bidirectional relationship. Alterations in these networks may also contribute to the underlying neurobiology of alcohol use disorder and stress-related disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.