Evidence map›Paper›PMID 41115976›Full record

ArticleNature communications2025

Apolipoprotein A-IV fibrils: structural diagnosis of mixed cardiac amyloidosis.

Shintaro Aibara, Astrid Kassner, Edmond Wong, Karin Klingel, Monika Papworth, Magnus Althage, Qing-Dong Wang, Claudia Correia, Hendrik Milting, Taiana Maia de Oliveira

Abstract read
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shintaro AibaraProtein Sciences, Structure, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Astrid KassnerHeart and Diabetes Center NRW, Bad Oeynhausen, Germany.
Edmond WongProtein Sciences, Structure, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK.
Karin KlingelCardiopathology, Institute for Pathology, University Hospital Tübingen,Liebermeisterstr. 8, Tübingen, Germany.
Monika PapworthBiologics Engineering, R&D, AstraZeneca, Cambridge, UK.
Magnus AlthageTranslational Science and Experimental Medicine, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Qing-Dong WangBioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.ORCID http://orcid.org/0000-0001-9570-4411
Claudia CorreiaBioscience Cardiovascular, Research and Early Development, Cardiovascular, Renal and Metabolism (CVRM), BioPharmaceuticals R&D, AstraZeneca, Gothenburg, Sweden.
Hendrik MiltingHeart and Diabetes Center NRW, Bad Oeynhausen, Germany. hendrik.milting@ruhr-uni-bochum.de.
Taiana Maia de OliveiraProtein Sciences, Structure, and Biophysics, Discovery Sciences, R&D, AstraZeneca, Cambridge, UK. taiana.maiadeoliveira@astrazeneca.com.ORCID http://orcid.org/0000-0003-3231-8112

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac amyloidosis (CA) occurs when misfolded proteins deposit as fibrils in the extracellular space of the heart. The fibrillogenic properties of apolipoprotein A-IV (ApoAIV) have been histologically observed and associated with CA pathogenesis. We report the structure of an ApoAIV amyloid from a patient's heart, which coexist amongst transthyretin (TTR) amyloids. These cases of undetected mixed CA highlight the importance of developing broad-spectrum anti-amyloid treatments to improve outcomes in patients.

Indexed as

AmyloidAmyloidosisApolipoproteins ACardiomyopathiesMyocardiumHumansPrealbuminAmyloidapolipoprotein A-IVApolipoproteins APrealbuminTTR protein, human

Identifiers

PMID41115976
PMCPMC12537937

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.