SynthesisJournal of assisted reproduction and genetics2025
Retrospective cohort study and meta-analysis of individualized luteal phase support with additional oral dydrogesterone in artificially prepared frozen embryo transfer cycles.
Synthesis in Journal of assisted reproduction and genetics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Pharmacodynamic interaction analysis of dydrogesterone, progesterone, and estradiol in combination-progestin HRT frozen embryo transfer: a prospective clinical cohort study.Reproductive biology and endocrinology : RB&E · 2026Article
- Serum progesterone levels for 'rescue' in hormone replacement FET: a retrospective cohort study of 917 cycles.Frontiers in endocrinology · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeDoes additional oral dydrogesterone (DYD) in luteal phase support enhance reproductive outcomes, in patients with low serum progesterone (P4) concentrations undergoing frozen-thawed embryo transfer (FET) with hormonal replacement therapy (HRT)?
methodsThis retrospective study analyzed 550 HRT cycles performed for FET between November 2020 and September 2023. Luteal phase support included micronized vaginal progesterone 400 mg twice daily. After two full day of progesterone administration, serum P4 levels were assessed: group 1 cycles with sufficient P4 levels continuing the routine protocol were compared to group 2 cycles with low serum P4 (< 11 ng/mL) who received additional oral DYD supplementation (10 mg three times daily). Primary outcome was live birth rate (LBR), with a multivariate regression analysis. A systematic review and meta-analysis of the current literature on DYD supplementation during HRT was also performed (PROSPERO registration number: CRD420250524058).
resultsInsufficient P4 levels were observed in 28.9% (159/550) of the studied cycles. LBR was comparable in both groups (24.16% [94/391] in group 1 and 27.22% [43/159] in group 2) and was not associated with the luteal support strategy (aOR 1.01, 95% CI [0.65-1.58], p = 0.96). In the meta-analysis, the ongoing pregnancy rate was similar in both groups (aOR 1.14, 95% CI [0.91-1.42]).
conclusionsIndividualized luteal phase support with DYD supplementation in patients with low luteal serum P4 levels during an HRT cycle for FET achieves LBR comparable to those observed in patients with adequate serum P4 levels, both in this cohort study and in a complementary meta-analysis.
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