Evidence map›Paper›PMID 41115943›Full record

ArticleNPJ microgravity2025

Neural correlates of vestibular adaptation in cosmonauts after long duration spaceflight.

Catho Schoenmaekers, Steven Jillings, Sepehr Mortaheb, Dmitrii Glukhikh, Ivan Naumov, Elena Tomilovskaya, Ilya Rukavishnikov, Ekaterina Pechenkova, Alexandra Ryabova, Lyudmila Makovskaya and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NPJ microgravity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Catho SchoenmaekersLab for Equilibrium Investigations and Aerospace, University of Antwerp, Antwerp, Belgium. catho.schoenmaekers@uantwerpen.be.
Steven JillingsLab for Equilibrium Investigations and Aerospace, University of Antwerp, Antwerp, Belgium.
Sepehr MortahebLab for Equilibrium Investigations and Aerospace, University of Antwerp, Antwerp, Belgium.
Dmitrii GlukhikhSSC-RF Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Ivan NaumovSSC-RF Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Elena TomilovskayaSSC-RF Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Ilya RukavishnikovSSC-RF Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Ekaterina PechenkovaLaboratory for Cognitive Research, HSE University, Moscow, Russia.
Alexandra RyabovaSSC-RF Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Lyudmila MakovskayaUniversity Clinic, MSU Lomonosov, Moscow, Russia.
Inna NosikovaSSC-RF Institute for Biomedical Problems, Russian Academy of Sciences, Moscow, Russia.
Peter Zu EulenburgInstitute for Neuroradiology, Ludwig-Maximilians-University Munich, Munich, Germany.
Floris L WuytsLab for Equilibrium Investigations and Aerospace, University of Antwerp, Antwerp, Belgium.

Funding

Belgian Science Policy (Prodex) ESA-AO-2004-093Fonds Wetenschappelijk Onderzoek 1SF9122NRussian Academy of Sciences FMFR-2024-0033
6 · The paper itself

Abstract

Long-duration spaceflight affects otolith-mediated ocular counter-roll (OCR) and brain function, but the relationship between these changes is unclear. This study examines whether OCR changes correlate with functional connectivity (FC) changes in the vestibular network in the same cosmonauts after a long-duration (6-month) spaceflight mission. Using a human vestibular atlas, we found that changes in FC between the right operculum (OP2_PIVC) and inferior parietal lobule (IPL, area PGp and PGa) were positively correlated with OCR changes. First-time flyers showed a greater decrease in OCR, linked to more significant FC reductions. Irrespective of the OCR, increased FC was observed postflight between the left visual cingulate cortex (CSv) and the anterior cingulate cortex (ACC, area 33), superior parietal lobule (SPL, area 5C), and thalamus (pulvinar), and between the right OP2_PIVC and SPL (area 5Ci). Secondly, decreased FC was observed between the left OP2_PIVC and the IPL (PGp) and SPL (area 7A). Additionally, increased FC postflight was observed between the left lateral sensorimotor area (LSM) and IPL (area PGp), and between the right lateral visual area (LVA) and cerebellum (Crus 1, Lobule VI). These findings suggest sensory reweighting and sensory system reorganization after long-duration spaceflight.

Identifiers

PMID41115943
PMCPMC12537990

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.