Evidence map›Paper›PMID 41115934›Full record

ArticleNature communications2025

RNA replicon vaccination confers long-lasting protection against H5N1 avian influenza in 23 zoo bird species.

Marion Stettler, Stefan Hoby, Christian Wenker, Fabia Wyss, Elisabeth Heiderich, Lisa Butticaz, Nicolas Ruggli, Karin Darpel, Gert Zimmer

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Counting cases, conserving species: addressing highly pathogenic avian influenza in wildlife.Biological reviews of the Cambridge Philosophical Society · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Marion StettlerBern Animal Park, Bern, Switzerland.
Stefan HobyBern Animal Park, Bern, Switzerland.
Christian WenkerZoo Basel, Basel, Switzerland.
Fabia WyssZoo Basel, Basel, Switzerland.
Elisabeth HeiderichBern Animal Park, Bern, Switzerland.
Lisa ButticazInstitute of Virology and Immunology IVI, Mittelhäusern, Switzerland.
Nicolas RuggliInstitute of Virology and Immunology IVI, Mittelhäusern, Switzerland.ORCID http://orcid.org/0000-0002-7679-6290
Karin DarpelInstitute of Virology and Immunology IVI, Mittelhäusern, Switzerland.
Gert ZimmerInstitute of Virology and Immunology IVI, Mittelhäusern, Switzerland. gert.zimmer@ivi.admin.ch.ORCID http://orcid.org/0000-0002-2708-2507

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Highly pathogenic avian influenza (HPAI) H5N1 viruses (clade 2.3.4.4b) cause mass mortality in birds and have infected over 50 mammalian species, including humans. Approved avian vaccines remain limited. We report the use of a propagation-defective vesicular stomatitis virus (VSV) replicon vaccine, VSV∆G(H5

Indexed as

Influenza A Virus, H5N1 SubtypeInfluenza in BirdsInfluenza VaccinesRepliconAnimalsAnimals, ZooAntibodies, NeutralizingAntibodies, ViralBirdsChickensHemagglutinin Glycoproteins, Influenza VirusSpecific Pathogen-Free OrganismsVaccinationVirus SheddingAntibodies, NeutralizingAntibodies, ViralHemagglutinin Glycoproteins, Influenza VirusInfluenza Vaccines

Identifiers

PMID41115934
PMCPMC12537987

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.