ArticleCell death discovery2025
Acidic melanoma microenvironment selects for a senescence-like but also migratory-active subpopulation driving metastatic disease.
Article in Cell death discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Mechanisms and therapeutic design of stimuli-responsive vesicular nanocarriers for melanoma.International journal of pharmaceutics: X · 2026Review
- Decoding the Role of Lipid Metabolism and Membrane Dynamics in Melanoma.International journal of molecular sciences · 2026Review
- Acidosis promotes exon skipping through sequestering SR-rich splicing factors in nuclear speckles.Frontiers in molecular biosciences · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the main characteristics of solid tumors, such as melanoma, is an acidic tumor microenvironment. Due to dysregulation of the cancer cell metabolism and an increased production of acidic metabolites, the tumor acidifies its microenvironment. We hypothesize that this has a strong impact on tumor heterogeneity and the formation of phenotypic subpopulations. Cell culture experiments are usually carried out at a physiological pH of 7.4. Here, we show that long-time acidosis results in the formation of a senescent subpopulation in melanoma cells. Interestingly, after reintroduction to physiological pH, these cells lose their senescence-associated attributes. We isolated this subpopulation using β-galactosidase-dependent C
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