ArticleNature communications2025
Thalamocortical hodology to personalize electrical stimulation for focal epilepsy.
Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Toward Optimizing Thalamic Deep Brain Stimulation for Cortical Modulation: A Surrogate Brain Approach.bioRxiv : the preprint server for biology · 2026Article
- Nucleus-specific thalamic involvement in seizure networks differentiates neuromodulation outcomes.medRxiv : the preprint server for health sciences · 2026Article
- Thalamic interictal epileptic and non-epileptic events during NREM sleep in patients with focal epilepsy: a Stereo-EEG study.EBioMedicine · 2026Article
- KArchiv der Pharmazie · 2026Review
- How Thalamo-Cortical Loops Modulate Cortico-Cortical Evoked Potentials?Brain topography · 2026Article
- Regional excitability, not epileptic pathology, drives stimulation-evoked interictal spike increases.medRxiv : the preprint server for health sciences · 2026Article
- A motor thalamic site in humans that suppresses involuntary breathing without awareness.Journal of neurophysiology · 2026Article
- Advances in Thalamic Neuromodulation for Epilepsy: From Mechanisms to Clinical Translation.Epilepsy currents · 2026Article
- Thalamocortical network dynamics in focal epilepsy: SEEG investigation.bioRxiv : the preprint server for biology · 2026Article
- Distinct Spectral and Directional Thalamocortical Network Dynamics Define Focal Seizure Evolution.medRxiv : the preprint server for health sciences · 2026Article
- Medial pulvinar stereoelectroencephalographic biomarkers associated with deep brain stimulation response in focal drug-resistant epilepsy.Epilepsia · 2026Article
- The Physics and Physiology of Electrical Stimulation of the Brain.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Article
- Biomarkers for Epilepsy Deep Brain Stimulation.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2025Review
- Epilepsy Surgery in the Last 10 Years: Advancements and Controversies.Epilepsy currents · 2025Review
- Anterior nucleus of thalamus deep brain stimulation for medication refractory epilepsy modulates theta and low-frequency gamma activity: a case study.Therapeutic advances in neurological disorders · 2025Article
- A comprehensive review of deep brain stimulation for drug-resistant epilepsy.Frontiers in neurologyReview
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12 authors.
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Abstract
Thalamic electrical stimulation offers a therapeutic approach for refractory epilepsy patients ineligibles for resective surgery. Yet, there is currently no consensus on the optimal stimulation site. We hypothesized that targeting thalamic nuclei with precise anatomical and functional connections (hodological matching) to cortical seizure onset zones (SOZs) could enhance neuromodulatory effects. Thus, we examined three subnuclei (pulvinar, anterior, and ventral intermediate/oral posterior, VIM/VOP) in 41 focal epilepsy patients. Combining neuroimaging and electrophysiology, we identified hodologically-matched targets: pulvinar for posterior-quadrant and temporal SOZs, anterior for frontotemporal, and VIM/VOP for rolandic. Analysis of 274 seizures revealed the critical role of matched nuclei in seizure termination. Stimulation of hodologically-matched (but not unmatched) nuclei immediately suppressed interictal epileptiform discharges. Finally, in 10 chronically implanted patients, matched stimulation substantially reduced seizure frequency (87.5%), compared to unmatched targets (8.3%) over time. Our results underscore the potential of hodological thalamic targeting to modulate epileptiform activity in focal epilepsy.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.