Evidence map›Paper›PMID 41115867›Full record

ArticleNature communications2025

Modular esterification of unstrained carbonyls through palladium-catalyzed alkyne bridging C-C bond activation.

Mingruo Ding, Mengmeng Niu, Lingfei Hu, Qifan Guan, Shan Yuan, Yinghua Yu, Maojun Xiao, Shenlin Huang, Gang Lu, Xueliang Huang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Alcohol-Directed Carboamination of Conjugated Enynes.Angewandte Chemie (International ed. in English) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Mingruo Ding *Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education of China, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, China.
Mengmeng Niu *Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education of China, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, China.
Lingfei Hu *Key Laboratory of Colloid and Interface Chemistry, School of Chemistry and Chemical Engineering, Ministry of Education, Shandong University, Jinan, China.
Qifan Guan *Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education of China, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, China.
Shan YuanKey Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education of China, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, China.
Yinghua YuState Key Laboratory of Structure Chemistry, Center for Excellence in Molecular Synthesis, Fujian Institute of Research on the Structure of Matter, Fujian College, Chinese Academy of Sciences, Fuzhou, Fujian, China.
Maojun XiaoKey Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education of China, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, China.
Shenlin HuangNational Key Laboratory for the Development and Utilization of Forest Food Resources, Nanjing Forestry University, Nanjing, China.ORCID http://orcid.org/0000-0001-7322-6981
Gang LuKey Laboratory of Colloid and Interface Chemistry, School of Chemistry and Chemical Engineering, Ministry of Education, Shandong University, Jinan, China. ganglu@sdu.edu.cn.ORCID http://orcid.org/0000-0002-7319-4315
Xueliang HuangKey Laboratory of Chemical Biology and Traditional Chinese Medicine Research, Ministry of Education of China, Key Laboratory of the Assembly and Application of Organic Functional Molecules of Hunan Province, College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha, Hunan, China. huangxl@hunnu.edu.cn.ORCID http://orcid.org/0000-0002-0079-9153

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The insertion of an oxygen atom into carbon-carbon (C-C) σ-bonds of readily available ketones to form esters represents a fundamental transformation known as Baeyer-Villiger (BV) oxidation. While this classical reaction serves as a cornerstone in organic synthesis, its scope remains limited to single oxygen-atom insertion into ketone substrates. We herein report a versatile catalytic protocol that enables the insertion of alkynyl phenol analogues into unstrained C-C σ-bonds of diverse carbonyl compounds, including ketones, esters, and amides. This method provides modular access to an array of structurally varied products ranging from linear esters to medium- and macrocyclic lactones. This methodology displays broad substrate scope, excellent functional group tolerance, direct applicability to bioactive molecule modification with effective transfer of axial chirality. An in-depth computational study provides insights into the reaction mechanism.

Identifiers

PMID41115867
PMCPMC12537825

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.