Evidence map›Paper›PMID 41115862›Full record

ArticleNature communications2025

CCL28 contributes to angiogenesis and cardiac repair through CCR10

Kun Yang, Hanchuan Chen, Yang Lyu, Wei Wei, Xiang Wei, Yunzhi Ling, Biting Lin, Gengyu Zhou, Juntao Chen, Jiaran Shi and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kun Yang *Department of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.
Hanchuan Chen *Department of Hypertension, Shanghai Institute of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Yang Lyu *Department of Cardiology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Wei Wei *Department of Cardiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China.
Xiang WeiDepartment of Cardiology, The Fifth People's Hospital of Shanghai, Fudan University, Shanghai, China.
Yunzhi LingDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.
Biting LinDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.
Gengyu ZhouDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China.
Juntao ChenDepartment of Urology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
Jiaran ShiDepartment of Cardiology, Lihuili Hospital Facilitated to Ningbo University, Ningbo, China. shijiaran102@126.com.ORCID http://orcid.org/0000-0002-2020-0830
Rifeng GaoDepartment of Cardiac Surgery, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. grfvictory@163.com.ORCID http://orcid.org/0000-0002-5453-8899
Kaiyang LinDepartment of Cardiology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China. lky7411@sina.com.ORCID http://orcid.org/0000-0003-1421-2728

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Secretome-based therapies that target angiogenesis are promising for the treatment of ischemic heart disease (IHD). The effects of Chemokine C-C motif ligand (CCL) 28 on IHD remain unclear. In this study, we investigated the role of CCL28 in angiogenesis during IHD in male mice using the myocardial infarction (MI) and hindlimb ischemia (HI) models. The upregulated CCL28/ C-C motif receptor (CCR)10 axis has been observed in HI and MI. Additionally, CCR10 is highly expressed in endothelial cells (ECs). Compared to CCR10

Indexed as

Chemokines, CCEndothelial CellsMyocardial InfarctionNeovascularization, PhysiologicReceptors, CCR10AngiogenesisAnimalsDisease Models, AnimalHindlimbHumansMaleMiceMice, Inbred C57BLMice, KnockoutSignal TransductionChemokines, CCReceptors, CCR10

Identifiers

PMID41115862
PMCPMC12537860

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.