Evidence map›Paper›PMID 41115826›Full record

ArticleBiotechnology progress

Dynamic pH profiles drive higher cell-specific and volumetric productivity.

Stephanie R Klaubert, Dylan G Chitwood, Danqia Peng, Erin Redman, Ji Young L Anderson, Nicholas R Sandoval, Sarah W Harcum

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biotechnology progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Stephanie R KlaubertDepartment of Chemical and Biomolecular Engineering, Clemson University, Clemson, South Carolina, USA.ORCID 0009-0005-7794-5680
Dylan G ChitwoodDepartment of Bioengineering, Clemson University, Clemson, South Carolina, USA.
Danqia PengDepartment of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Louisiana, USA.
Erin RedmanDepartment of Research and Development, 908 Devices, Inc., Morrisville, North Carolina, USA.
Ji Young L AndersonDepartment of Research and Development, 908 Devices, Inc., Boston, Massachusetts, USA.
Nicholas R SandovalDepartment of Chemical and Biomolecular Engineering, Tulane University, New Orleans, Louisiana, USA.
Sarah W HarcumDepartment of Bioengineering, Clemson University, Clemson, South Carolina, USA.ORCID 0000-0001-9417-0489

Funding

National Science Foundation OIA-1736123
6 · The paper itself

Abstract

Mammalian cell cultures in bioreactors rely heavily on critical process parameter control to ensure optimal growth, productivity, and reproducibility to produce recombinant therapeutic proteins. Culture pH has been shown to be a critical parameter that influences growth, productivity, and critical quality attributes. Typically, pH is either controlled to a set-point throughout the culture or uses a single pH shift to achieve higher productivity and more desirable charge variant profiles. The pH is usually maintained by CO

Indexed as

BioreactorsCell Culture TechniquesAnimalsCarbon DioxideCHO CellsCricetinaeCricetulusGlycosylationHydrogen-Ion ConcentrationImmunoglobulin GRecombinant ProteinsCarbon DioxideImmunoglobulin GRecombinant ProteinsCHOCO2 accumulationfed‐batchpH controlproductivityproduct quality

Identifiers

PMID41115826
PMCPMC12908104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.