Evidence map›Paper›PMID 41115789›Full record

Observational studyThe International journal of eating disorders2026

Maladaptive Exercise in People With a Lifetime History of Eating Disorders: A Multicountry Observational Study.

Hunna J Watson, Katherine Schaumberg, Laura M Thornton, Hannah L Kennedy, Shu H Ong, Preston Roche, Wesley R Barnhart, Sian B Pauley-Gadd, Kayla Costello, Rachael E Flatt and 13 more

Registry-linked trialAbstract readObservational StudyMulticenter Study
In one paragraph

Observational study in The International journal of eating disorders, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04378101 (Eating Disorders Genetics Initiative), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04378101 completednot on this map

Eating Disorders Genetics Initiative (EDGI)

TypeobservationalSponsorUniversity of North Carolina, Chapel HillRan2020 to 2023Enrolled17,991ConditionsAnorexia Nervosa, Bulimia Nervosa, Binge-Eating DisorderArmsEating disorder diagnosis group
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Hunna J WatsonDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0001-8405-381X
Katherine SchaumbergDepartment of Psychology, University of Texas, Austin, Texas, USA.ORCID https://orcid.org/0000-0003-3193-2233
Laura M ThorntonDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0001-9384-7988
Hannah L KennedyDepartment of Psychological Medicine, University of Otago Christchurch, Christchurch, New Zealand.ORCID https://orcid.org/0000-0002-5393-8348
Shu H OngInsideOut Institute for Eating Disorders, The University of Sydney and Sydney Local Health District, Sydney, Australia.ORCID https://orcid.org/0000-0003-3364-0111
Preston RocheDepartment of Psychiatry and Behavioral Sciences, University of Texas at San Antonio, San Antonio, Texas, USA.ORCID https://orcid.org/0009-0004-5825-7949
Wesley R BarnhartDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-9809-5225
Sian B Pauley-GaddDiscipline of Psychology, School of Population Health, Curtin University, Perth, Australia.ORCID https://orcid.org/0009-0008-8865-1567
Kayla CostelloDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-5486-9647
Rachael E FlattDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0002-2661-7987
Andreas BirgegårdDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0003-1220-9680
Lisa DinklerDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-9901-4984
Afrouz AbbaspourDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-1337-0102
Emma Forsén MantillaDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0001-9550-3820
Elin MonellDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-3305-4844
Emma M FransDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.ORCID https://orcid.org/0000-0002-9791-687X
Sarah BarakatInsideOut Institute for Eating Disorders, The University of Sydney and Sydney Local Health District, Sydney, Australia.ORCID https://orcid.org/0000-0002-3097-8320
Michaela A PettieDepartment of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand.ORCID https://orcid.org/0000-0001-5466-8848
Richard ParkerQIMR Berghofer Medical Research Institute, University of Queensland, Brisbane, Australia.ORCID https://orcid.org/0000-0003-1451-5622
Sarah MaguireInsideOut Institute for Eating Disorders, The University of Sydney and Sydney Local Health District, Sydney, Australia.ORCID https://orcid.org/0000-0003-0754-9189
Jennifer JordanDepartment of Psychological Medicine, University of Otago Christchurch, Christchurch, New Zealand.ORCID https://orcid.org/0000-0003-4699-6301
Martin A KennedyDepartment of Pathology and Biomedical Science, University of Otago Christchurch, Christchurch, New Zealand.ORCID https://orcid.org/0000-0002-6445-8526
Cynthia M BulikDepartment of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.ORCID https://orcid.org/0000-0001-7772-3264

Funding

Re-Entry Supplement: Investigation of Oral Microbial Enzymes for the Detection and Treatment of Periodontal DiseaseUL1TR002489 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, SHAHEEN, NICHOLAS J · 2018 to 2022
$48.6M
North Carolina Translational & Clinical Sciences Institute (NC TraCS)UL1TR001111 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BUSE, JOHN BERNARD, CAREY, TIMOTHY S · 2013 to 2017
$43.9M
North Carolina Translational and Clinical Sciences Institute (NC TraCS)UM1TR004406 · NCATS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI NICHOLAS J SHAHEEN · 2023 to 2026
$37.5M
Eating Disorders Genetics Initiative (EDGI)R01MH120170 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M · 2019 to 2023
$7.2M
Predicting the multi-omic impact of psychiatric GWAS associationsR01MH118278 · NIMH · YALE UNIVERSITY · PI HUCKINS, LAURA MARIANNE · 2019 to 2023
$3.6M
1/7 PGC: Advancing Discovery and ImpactR01MH124871 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, SULLIVAN, PATRICK F · 2021 to 2025
$3.5M
Predicting Binge and Purge Episodes from Passive and Active Apple Watch Data Using a Dynamical Systems ApproachR01MH119084 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, BUTNER, JONATHAN · 2019 to 2022
$2.8M
1/7 Psychiatric Genomics Consortium: Finding actionable variationU01MH109528 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI SULLIVAN, PATRICK F · 2016 to 2020
$2.5M
Genetic Architecture of Avoidant/Restrictive Food Intake DisorderR56MH129437 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI BULIK, CYNTHIA M, MICALI, NADIA · 2022 to 2023
$1.5M
Driven exercise and risk for eating disorders: A combined genetic and longitudinal epidemiological investigationK01MH123914 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI SCHAUMBERG, KATHERINE · 2020 to 2023
$743k
Fredrik and Ingrid Thurings Foundation (Thurings stiftelse) 2021-00660Lundbeck FoundationNational Institute of Mental Health (NIMH) K01MH123914National Institute of Mental Health (NIMH) L30MH120619National Institute of Mental Health (NIMH) R01MH118278National Institute of Mental Health (NIMH) R01MH119084National Institute of Mental Health (NIMH) R01MH120170National Institute of Mental Health (NIMH) R01MH124871National Institute of Mental Health (NIMH) R56MH129437NCATS NIH HHS UL1 TR001111NCATS NIH HHS UL1 TR002489NCATS NIH HHS UM1 TR004406NIH HHS UL1TR001111NIH HHS UL1TR002489NIMH NIH HHS K01 MH123914NIMH NIH HHS L30 MH120619NIMH NIH HHS R01 MH118278NIMH NIH HHS R01 MH119084NIMH NIH HHS R01 MH120170NIMH NIH HHS R01 MH124871NIMH NIH HHS R56 MH129437NIMH NIH HHS U01 MH109528Swedish Mental Health FoundationSwedish Research Council 538-2013-8864Swedish Research Council R276-2018-4581Swedish Society for Medical Research (SSMF) PG-22-0478
6 · The paper itself

Abstract

objectiveMaladaptive exercise (ME), problematic attitudes or behaviors related to physical activity, is often observed in eating disorders (EDs), but its prevalence, severity, and relationships with ED features remain incompletely characterized. This study aimed to describe lifetime and current ME across ED diagnoses, examine associations with ED symptoms, sociodemographic characteristics, and weight status, and compare ME phenotypes to identify those most strongly linked to ED features.

methodsME was assessed in 31,671 individuals with lifetime EDs (anorexia nervosa [AN], bulimia nervosa, and binge-eating disorder [BED]) recruited to sites in the United States, Australia, New Zealand, and Sweden as part of the Eating Disorders Genetics Initiative (NCT04378101). We examined one lifetime ME phenotype, capturing any occurrence of ME across the lifespan (derived from the ED100K), and five current ME phenotypes (any driven exercise [Eating Disorder Examination-Questionnaire, EDE-Q], frequency of driven exercise [EDE-Q], regular driven exercise [EDE-Q], compulsive exercise test [CET] total, and dichotomous compulsive exercise [CET]).

resultsLifetime ME was highly prevalent across countries and ED diagnoses (pooled prevalence 88%). Current ME was also common (40% any driven exercise, 35% compulsive exercise, and 12% regular driven exercise), highest in AN and lowest, but notable, in BED. CET-based phenotypes showed the strongest association with ED symptoms, while EDE-Q-derived regular driven exercise was most strongly associated with underweight (BMI < 18.5). Younger generations exhibited a higher ME risk, likely reflecting societal shifts in body ideals and fitness culture. DISCUSSION: This large, multicountry study demonstrates that ME is highly prevalent across EDs, often emerges early, and can persist or recur for decades. Prevalence and severity vary considerably by assessment method. The ED100K, CET, and EDE-Q capture complementary aspects of ME, and incorporating all three may improve clinical care. We recommend that clinicians assess both current and lifetime ME in all patients with EDs. Routine, harmonized assessment will be essential to advancing research and improving patient outcomes.

trial registrationClinicalTrials.gov identifier: NCT04378101.

Indexed as

ExerciseFeeding and Eating DisordersAdolescentAdultAustraliaFemaleHumansMaleMiddle AgedNew ZealandPhenotypePrevalenceSwedenUnited StatesYoung Adultcompulsive exerciseeating disordersEating Disorders Genetics Initiative (EDGI)exercisemaladaptive exercisephysical activity

Identifiers

PMID41115789
PMCPMC12594026

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.