Evidence map›Paper›PMID 41115453›Full record

ArticleNature2026

Parity and lactation induce T-cell-mediated breast cancer protection.

Balaji Virassamy, Franco Caramia, Peter Savas, Michael A Harris, Jia-Wern Pan, Jianan Wang, Emmaline Brown, Megan M R O'Malley, Courtney T van Geelen, Michael Hun and 22 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. The immunology of human breast cancer.Nature reviews. Immunology · 2026
    Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. LifelongNutrients · 2026
    Article
  15. Motherhood Imprints Tissue-Resident CD8Research (Washington, D.C.) · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Tissue-resident memory T cells reshapeFrontiers in immunology · 2026
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Balaji Virassamy *Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-7341-8104
Franco Caramia *Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Peter Savas *Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0001-5999-428X
Michael A Harris *Division of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-9904-4091
Jia-Wern PanCancer Research Malaysia, Subang Jaya, Malaysia.ORCID 0000-0003-0875-9831
Jianan WangDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-5213-8330
Emmaline BrownDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Megan M R O'MalleyDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Courtney T van GeelenDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-2716-9135
Michael HunDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Thomas N BurnDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.ORCID 0000-0003-1763-1418
Sneha SantDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Jamieson D BallanDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0009-0008-9011-914X
Jasmine KayDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0009-0009-6673-6604
Luis E Lara GonzalezDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0003-3897-353X
Kylie ClarkeDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Han Xian Aw YeangDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-1705-692X
Rejhan IdriziDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Metta JanaDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0001-7092-045X
Damon J ChalliceDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Roberto SalgadoDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-1110-3801
Heather ThorneDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
kConFab consortium
Cathie PolinessDepartment of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Sophie NightingaleDepartment of Cancer Surgery, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.
Soo-Hwang TeoCancer Research Malaysia, Subang Jaya, Malaysia.
Terence P SpeedBioinformatics and Computational Biology Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.ORCID 0000-0002-5403-7998
Jane VisvaderCancer Biology and Stem Cells Division, The Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.ORCID 0000-0001-9173-6977
Paul J NeesonDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-2729-5887
Phillip K DarcyDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia.ORCID 0000-0002-5303-9561
Laura K MackayDepartment of Microbiology and Immunology, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia. lkmackay@unimelb.edu.au.ORCID 0000-0002-8496-6632
Sherene LoiDivision of Cancer Research, Peter MacCallum Cancer Centre, Melbourne, Victoria, Australia. sherene.loi@petermac.org.ORCID 0000-0001-6137-9171

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Parity and breastfeeding reduce the risk of breast cancer, particularly triple-negative breast cancer (TNBC)

Indexed as

Breast NeoplasmsCD8-Positive T-LymphocytesLactationParityTriple Negative Breast NeoplasmsAdultAnimalsDisease Models, AnimalFemaleHumansImmunologic MemoryMicePregnancy

Identifiers

PMID41115453
PMCPMC12779547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.