ArticleAnnals of internal medicine2025
Trends in Cancer Incidence in Younger and Older Adults : An International Comparative Analysis.
Article in Annals of internal medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Trends in early-onset cancer incidence rates in the Nordic countries (2003-2022): a population-based study.The Lancet regional health. Europe · 2026Article
- Article
- Closing the Diagnostic Gap in Early-Onset Colorectal Cancer: Red-Flag Symptoms, Screening, and Inherited Risk.Cancers · 2026Review
- Review
- Tumor Vascular Features and Colorectal Cancer-Specific Mortality.JAMA network open · 2026Article
- Biological aging and generational shifts in early-onset cancer risk.Nature medicine · 2026Article
- Glucagon-like peptide-1 receptor agonist use and risk of gynecologic cancers: a meta-analysis of multinational real-world cohort studies.Preventive medicine reports · 2026Article
- Cancer trends in England in younger adults from 2001-2023: comparing incidence, mortality and stage at diagnosis.medRxiv : the preprint server for health sciences · 2026Article
- Increasing Burden of Early-Onset Cancers: Disentangling the Contributions of Changes in Risk from Demographic Shifts.Cancer research communications · 2026Article
- Epigenetic fingerprints link early-onset colon and rectal cancer to pesticide exposure.Nature medicine · 2026Article
- Accelerating discovery of cancer causes for prevention in the era of rising early-onset cancers.Cell · 2026Review
- Cytotoxic T-cell exhaustion analyses by in situ single-cell immunofluorescence in relation to colorectal cancer patient age, tissue bacteria and mortality.BMJ oncology · 2026Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is concern about widespread increases in cancer incidence rates in younger adults.
objectiveTo compare international cancer incidence trends in younger adults (aged 20 to 49 years) and older adults (aged ≥50 years).
designSurveillance study.
settingForty-two countries in Asia (
participantsAdults aged 20 years or older. MEASUREMENTS: Joinpoint regression to estimate the average annual percentage change (AAPC) in cancer incidence rates for 13 cancer types previously reported to be increasing in multiple countries in younger adults (leukemia and breast, endometrial, colorectal, oral, kidney, liver, pancreatic, gallbladder, prostate, stomach, esophageal, and thyroid cancer).
resultsIncidence rates increased in younger adults in most (>75%) countries between 2003 and 2017 for 6 of the 13 cancer types: thyroid cancer (median AAPC, 3.57%), breast cancer (median AAPC, 0.89%), colorectal cancer (median AAPC, 1.45%), kidney cancer (median AAPC, 2.21%), endometrial cancer (median AAPC, 1.66%), and leukemia (median AAPC, 0.78%). Incidence rates for these cancer types also increased in older adults in most countries (median AAPCs, 3% for thyroid cancer, 0.86% for breast cancer, 1.65% for kidney cancer, 1.20% for endometrial cancer, and 0.61% for leukemia). The exception was colorectal cancer, which only increased in older adults in about half the countries (median AAPC, 0.37%), and the AAPC was greater in younger than older adults in 69% of countries. For liver, oral, esophageal, and stomach cancer, rates decreased in younger adults in more than half the countries. LIMITATION: Most countries with available data were high-middle-income countries, and the results might not be generalizable.
conclusionCancer incidence rates increased for several cancer types in many of the countries studied; however, other than colorectal cancer, these increases occurred in both younger and older adults. These findings can help inform future research and clinical and public health guidelines. PRIMARY FUNDING SOURCE: Institute of Cancer Research and National Institutes of Health Intramural Research Program.
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