ArticleJournal of the American Chemical Society2025
Efficient Assembly of Functional RNA by
Article in Journal of the American Chemical Society, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed.
- Emerging strategies and innovations in circular RNA synthesis.Molecular therapy. Nucleic acids · 2026Review
- A nucleic acid labeling chemistry reveals surface DNA on exosomes.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Influence of Phosphate Activation Chemistry on the Selection of the Primordial Genetic Alphabet.Journal of the American Chemical Society · 2026Article
- A nucleic acid labeling chemistry reveals surface DNA on exosomes.bioRxiv : the preprint server for biology · 2025Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How ribozymes might have emerged prior to the evolution of an efficient RNA replicase remains an open question. A potential solution involves the nonenzymatic ligation of RNA oligomers that are short enough to have been replicated by nonenzymatic chemistry. However, the high concentrations of metal ions that facilitate ligation are incompatible with primitive protocells. In addition, the mode of oligoribonucleotide 5'-phosphate activation is unclear, and in an aqueous environment the competing hydrolysis of such activated intermediates limits ligation efficiency. In this study, we have investigated the template-independent assembly of structured RNAs via loop-closing ligation using a potentially prebiotic
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Registered trials
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