Evidence map›Paper›PMID 41115167›Full record

ArticleCirculation2025

Direct Therapeutic Modulation of RYR2 Activity by CMYA5.

Fujian Lu, Zexuan Wu, Shaopeng Chi, Yangong Wang, Anna Ponek, Qing Ma, Chunjing Chen, Bingbing Shi, Nikoleta Pavlaki, Carter Liou and 11 more

Abstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. An RYR2-interacting fragment of MYBPC3 mitigates arrhythmia in human iPSC-CM and mouse models of CPVT.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Fujian Lu *Institutes of Biomedical Sciences, Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, China (F.L., Y.W., C.C., B.S., Z.G.).ORCID 0000-0003-3605-3924
Zexuan Wu *Department of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).ORCID 0000-0003-3726-773X
Shaopeng Chi *Department of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).
Yangong WangInstitutes of Biomedical Sciences, Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, China (F.L., Y.W., C.C., B.S., Z.G.).
Anna PonekDepartment of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).ORCID 0009-0008-5366-881X
Qing MaDepartment of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).ORCID 0000-0002-5625-1330
Chunjing ChenInstitutes of Biomedical Sciences, Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, China (F.L., Y.W., C.C., B.S., Z.G.).
Bingbing ShiInstitutes of Biomedical Sciences, Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, China (F.L., Y.W., C.C., B.S., Z.G.).ORCID 0009-0000-9310-8237
Nikoleta PavlakiDepartment of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).ORCID 0000-0001-5484-192X
Carter LiouDepartment of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).ORCID 0009-0000-2577-4350
Yashasvi TharaniDepartment of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).ORCID 0000-0002-3551-3362
Maksymilian ProndzynskiDepartment of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).
Sanam Shafaat TalabDepartment of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).ORCID 0000-0002-1127-8409
Wenjun XieDepartment of Cardiology, The First Affiliated Hospital, Xi'an Jiaotong University, Shaanxi, China (W.X.).ORCID 0000-0003-0493-062X
Yu Seby ChenDepartment of Biochemistry and Molecular Biology, The Life Sciences Institute, University of British Columbia, Vancouver, Canada (Y.S.C., F.v.P.).ORCID 0000-0002-0793-2391
Zengpin GuoInstitutes of Biomedical Sciences, Department of Cardiology, Zhongshan Hospital, Shanghai Institute of Cardiovascular Diseases, Fudan University, China (F.L., Y.W., C.C., B.S., Z.G.).
Stuart R LipsitzDepartment of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).ORCID 0000-0003-2619-1389
Donghui ZhangState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, Wuhan, China (D.Z.).
Filip van PetegemState Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Science, Hubei University, Wuhan, China (D.Z.).
Vassilios J BezzeridesDepartment of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).ORCID 0000-0003-0825-6580
William T PuDepartment of Cardiology, Boston Children's Hospital, MA (F.L., Z.W., S.C., A.P., Q.M., N.P., C.L., Y.T., M.P., S.S.T., S.R.L. V.J.B., W.T.P.).ORCID 0000-0002-4551-8079

Funding

Tissue chips for precision treatment of catecholaminergic polymorphic ventricular tachycardia - Diversity Supplement for Nnaemeka Justin AnyanwuUH3TR003279 · NCATS · BOSTON CHILDREN'S HOSPITAL · PI PARKER, KEVIN KIT, PU, WILLIAM TSWENCHING · 2022 to 2024
$2.5M
CMYA5 regulation of cardiac dyad structure and functionR01HL163937 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI William Tswenching Pu · 2023 to 2026
$2.4M
CMYA5 modulates ryanodine receptor 2 (RYR2) activity in cardiomyocytesF32HL179833 · NHLBI · BOSTON CHILDREN'S HOSPITAL · PI CHI, SHAOPENG · 2025 to 2025
$86k
NCATS NIH HHS UH3 TR003279NHLBI NIH HHS F32 HL179833NHLBI NIH HHS R01 HL163937
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

catecholaminergic polymorphic ventricular tachycardiagene therapyryanodine receptor calcium release channel

Identifiers

PMID41115167
PMCPMC12616379

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.