Evidence map›Paper›PMID 41115065›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2025

Resting beat-to-beat blood pressure variability is preserved in young adults with major depressive disorder.

Ashley M Darling, Benjamin E Young, Cynthia M Dominguez, Jeremiah A Joseph, Paul J Fadel, Erika F H Saunders, Jody L Greaney

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Individuals with posttraumatic stress disorder have increased beat-to-beat blood pressure variability.American journal of physiology. Regulatory, integrative and comparative physiology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ashley M DarlingDepartment of Kinesiology, The University of Texas at Arlington, Arlington, Texas, United States.
Benjamin E YoungDepartment of Applied Clinical Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States.ORCID 0000-0003-0239-005X
Cynthia M DominguezDepartment of Bioengineering, The University of Texas at Arlington, Arlington, Texas, United States.ORCID 0009-0003-0456-7637
Jeremiah A JosephDepartment of Kinesiology, The University of Texas at Arlington, Arlington, Texas, United States.ORCID 0009-0001-2046-2531
Paul J FadelDepartment of Kinesiology, The University of Texas at Arlington, Arlington, Texas, United States.ORCID 0000-0002-0115-0743
Erika F H SaundersDepartment of Psychiatry and Behavioral Health, Penn State College of Medicine, Hershey, Pennsylvania, United States.ORCID 0000-0001-7222-0828
Jody L GreaneyDepartment of Kinesiology, The University of Texas at Arlington, Arlington, Texas, United States.ORCID 0000-0002-9855-3978

Funding

Peripheral and Central Mechanisms of Neurovascular Dysfunction in Human DepressionR00HL133414 · NHLBI · UNIVERSITY OF TEXAS ARLINGTON · PI GREANEY, JODY · 2019 to 2021
$746k
Daily stress processes and sympathetic reactivity in depressionR21MH123928 · NIMH · UNIVERSITY OF TEXAS ARLINGTON · PI GREANEY, JODY · 2021 to 2022
$521k
Peripheral and Central Mechanisms of Neurovascular Dysfunction in Human DepressionK99HL133414 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI GREANEY, JODY · 2017 to 2018
$209k
HHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL133414HHS | NIH | National Institute of Mental Health (NIMH) MH123928NHLBI NIH HHS K99 HL133414NHLBI NIH HHS R00 HL133414NIMH NIH HHS R21 MH123928
6 · The paper itself

Abstract

Major depressive disorder (MDD) often first emerges during young adulthood and is associated with an increased risk of future hypertension, but our understanding of blood pressure (BP) regulation in young adults with MDD who are otherwise clinically healthy remains limited. We tested the hypothesis that beat-to-beat BP variability (BPV) would be greater in young unmedicated adults with MDD compared with nondepressed healthy adults (HA). Because the arterial baroreflex is essential for beat-to-beat BP regulation, we also hypothesized that

Indexed as

BaroreflexBlood PressureMajor Depressive DisorderRestAdultCase-Control StudiesFemaleHeart RateHumansMaleSympathetic Nervous SystemYoung Adultdepressionmicroneurographymuscle sympathetic nerve activitysympathetic baroreflex sensitivity

Identifiers

PMID41115065
PMCPMC12576842

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.