ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
Self-Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- 3D-printed dictamni-calcium silicate scaffolds modulate the osteoimmune microenvironment and enhance macrophage-derived exosomal miR-21 signaling in vascularized bone regeneration.Journal of nanobiotechnology · 2026Article
- Self-Assembled Dictamni Cortex Nanoparticles Ameliorate Psoriasis by Epigenetic Modulation of HSP90AB1 and Suppression of the Inflammatory Response.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nanodelivery of Gentiopicroside for Inflammatory Skin Lesions: Insights from Psoriasis and Diabetic Foot Ulcers.International journal of nanomedicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
Psoriasis, a chronic immune-mediated dermatological disease with high recurrence rates and limited therapeutic efficacy, requires novel treatment strategies. Dictamni Cortex (BXP), a traditional Chinese medicine (TCM), has demonstrated potential in alleviating psoriasis; however, its clinical application is hampered by poor water solubility and low bioavailability. It is developed infinite coordination polymer nanoparticles (BXP-Fe (III) ICPs, NB), which enhance the aqueous solubility by 95-fold and bioavailability of BXP, exerting therapeutic effect through efficient transdermal delivery. NB significantly suppresses keratinocyte hyperproliferation, inflammation, and oxidative stress in both M5 (a cocktail of cytokines)-treated human epidermal keratinocytes (HEKa) cells and imiquimod (IMQ)-induced psoriatic mice. Nascent proteomics identified heat shock protein 90 alpha family class B member 1 (HSP90AB1) as a key target downregulated by NB. It is further revealed that NB suppresses HSP90AB1 transcription by inhibiting its activator, CCCTC-binding factor (CTCF), and disrupts the HSP90AB1-CDC37 (cell division cycle 37, the co-chaperone) chaperone complex, thereby inactivating the pivotal client proteins STAT3 and Akt. Notably, NB demonstrated superior therapeutic efficacy over the canonical HSP90 inhibitor AUY922. This study highlights NB as a promising topical nanotherapy for psoriasis, integrating TCM with modern nanotechnology to overcome pharmacological limitations. The underlying molecular mechanisms of NB are elucidated through the CTCF-HSP90AB1-STAT3 axis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.