Evidence map›Paper›PMID 41114874›Full record

SynthesisLasers in medical science2025

Effects of Cold Atmospheric Plasma on Cellular Behavior in Oral and Dental Tissues: A Systematic Review.

Mahdi Kadkhodazadeh, Negar Dehghani, Sara Nashibi, Shaghayegh Khoshgou, Ali Azadi, Reza Amid, Nozhan Azimi

Abstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mahdi Kadkhodazadeh *Dental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Negar DehghaniFaculty of Dentistry, Islamic Azad University Tehran Medical Sciences, Tehran, Iran.
Sara NashibiDentofacial Deformities Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Shaghayegh KhoshgouDepartment of Periodontics, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ali AzadiDentofacial Deformities Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Reza AmidDental Research Center, Research Institute of Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nozhan Azimi *Dentofacial Deformities Research Center, Research Institute for Dental Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran. nozhanazimi@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeCold Atmospheric Plasma (CAP) is known for its ability to interact with living tissues without causing thermal damage. In dentistry, CAP has been explored for its potential for direct therapeutic applications, such as tissue regeneration, wound healing, and sterilization. CAP is currently transitioning from strong preclinical evidence to limited but growing clinical use, mainly within specialized research settings. This study aimed to systematically review the current literature on the effects of CAP on oral and dental tissue cell behavior, focusing on outcomes like proliferation, differentiation, apoptosis, wound healing, and anti-inflammatory responses.

methodsA comprehensive search was conducted in PubMed, Web of Science, and Scopus databases up to February 2025, addressing the following PICO question: "What is the effect of CAP (I) on the behavior of oral and dental tissue cells (P) compared to standard treatments or no treatment (C) in the context of dental therapies concerning outcomes such as proliferation, differentiation, apoptosis, wound healing, or anti-inflammatory effects (O)?". Studies that investigated the direct application of CAP on relevant cell types in dental contexts were included. Risk of bias was assessed using the risk of bias tool for animal intervention studies (SYRCLE's RoB tool) and JBI Critical Appraisal Tool for Assessment of Risk of Bias for Randomized Controlled Trials.

resultsThe search yielded 964 studies. A total of 29 studies were included in the review: 22 in vitro, 8 in vivo, and 1 clinical study. CAP promoted oral tissue healing by enhancing cell proliferation, migration, and wound closure, with low cytotoxicity. It also reduced inflammation and modulated immune responses, supporting regenerative processes in oral tissues.

conclusionCAP facilitates tissue repair by promoting cell activity, reducing inflammation, and inducing osteogenic differentiation. However, extended exposure may cause harmful effects such as apoptosis and inflammation, emphasizing the need for precise control of exposure for effective therapeutic outcomes.

Indexed as

MouthPlasma GasesAnimalsApoptosisCell DifferentiationCell ProliferationHumansWound HealingPlasma GasesGingival fibroblastNon-Thermal Atmospheric Pressure PlasmaPeriodontal LigamentPlasma Gases

Identifiers

PMID41114874

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.