ArticleLangenbeck's archives of surgery2025
Elevated circulating dipeptidyl peptidase 3 (cDPP3) as a predictor of postoperative complications in esophagectomy patients.
Article in Langenbeck's archives of surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
purposeEsophagectomy for esophageal cancer carries high postoperative morbidity and mortality. Circulating dipeptidyl peptidase 3 (cDPP3) is a novel biomarker linked to organ failure in acute care. This study evaluates its prognostic value for predicting organ dysfunction and mortality post-esophagectomy.
methodsThis prospective, single-center study included 20 esophagectomy patients. cDPP3 levels were measured preoperatively and at 24, 72, 120, and 168 h postoperatively using a Nexus IB10 Analyzer. Postoperative complications, including pneumonia, anastomotic insufficiency, and SOFA score-based organ dysfunction, were recorded. Correlation analysis assessed associations between cDPP3 levels and clinical outcomes.
resultsAmong 20 patients, the most common complications were pneumonia (n = 12), sepsis (n = 17), and anastomotic insufficiency (n = 5). Elevated cDPP3 levels correlated with SOFA score increases ≥ 2 (p < 0.01) and severe complications, including prolonged ICU stays. cDPP3 levels at 72 h were significantly associated with anastomotic insufficiency (p < 0.01). A negative correlation was observed between intraoperative volume and cDPP3 levels at 24 h (r = -0.495, p = 0.03).
conclusionscDPP3 is a potential biomarker for postoperative complications after esophagectomy. Its elevation correlates with increased morbidity, highlighting the need for vigilant perioperative management.
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