Evidence map›Paper›PMID 41114793›Full record

ArticleVirchows Archiv : an international journal of pathology2025

A pediatric low-grade sinonasal mesenchymal tumor harboring a novel CHD9::BEND2 fusion.

Huiting Wei, Dawei Liu, Yanan Li, Huijuan Shi, Sheng Xiao, Anjia Han

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Article in Virchows Archiv : an international journal of pathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Huiting Wei *Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Dawei Liu *Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Yanan LiDepartment of Biosciences and Bioinformatics, Xi'an Jiaotong-Liverpool University, Suzhou, China.
Huijuan ShiDepartment of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.
Sheng XiaoDepartment of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Anjia HanDepartment of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China. hananjia@mail.sysu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BEND2-rearranged neoplasms represent a newly emerging group of tumors with variable morphology, involving multiple tissue types and anatomical sites such as the central nervous system, bone, soft tissue, and salivary glands. Here, we describe a novel CHD9::BEND2 fusion in a low-grade spindle cell mesenchymal tumor arising in the sinonasal tract of a 5-year-old girl. Histologically, the tumor exhibited ovoid to spindle-shaped cells with moderate atypia, numerous thin-walled vessels, and focal necrosis. Immunohistochemistry did not indicate a specific line of differentiation, showing focal SATB2 positivity and a low proliferative index. The CHD9::BEND2 fusion was identified by whole transcriptome sequencing and confirmed by RT-PCR, Sanger sequencing, and break-apart FISH. This case broadens the clinicopathological and molecular spectrum of BEND2-associated tumors, suggesting a potential oncogenic role of CHD9::BEND2 in pediatric mesenchymal neoplasia.

Indexed as

BEND2-rearranged tumorCHD9::BEND2 fusionPediatric spindle cell neoplasmRNA sequencingSinonasal mesenchymal tumor

Identifiers

PMID41114793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.