ArticleClinical oral investigations2025
Antibacterial activity and physicochemical properties of light-curable fluoride varnishes containing strontium phosphate-based glass.
Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
objectivesLight-curable fluoride varnishes (LCFVs) have demonstrated enhanced long-term protection of the enamel compared to conventional fluoride varnishes. Strontium-containing phosphate-based glass (Sr-PBG) exhibits antibacterial activity and promotes remineralization through sustained release of calcium, phosphate, and strontium ions. This study aimed to evaluate the antibacterial efficacy and physicochemical properties of LCFVs containing various concentrations of Sr-PBG.
methodsExperimental LCFVs were formulated by incorporating Sr-PBG powder at concentrations of 0 (control), 1.0, 5.0, and 10.0 wt%. Antibacterial effects were assessed by colony-forming units (CFU) of Streptococcus mutans (S. mutans) after 24 and 48 h of incubation, and bacterial adhesion was examined by scanning electron microscopy (SEM). The physicochemical properties, including the degree of conversion, film thickness, contact angle, SEM, and ion release, were evaluated. Data were analyzed using one-way analysis of variance and Tukey's post-hoc tests (α = 0.05).
resultsAll Sr-PBG groups exhibited significantly reduced S. mutans CFU compared to the control (p < 0.05), with antibacterial effects enhanced by longer incubation. Sr-PBG incorporation did not significantly alter the degree of conversion or film thickness (p > 0.05). The contact angle significantly decreased only for 5.0 wt% Sr-PBG (p < 0.05). SEM analysis showed slight particle agglomeration at higher Sr-PBG concentrations, whereas the ion release of Sr and P significantly increased (p < 0.05).
conclusionsIncorporating ≥ 1.0 wt% Sr-PBG into LCFVs significantly enhanced antibacterial activity against S. mutans without compromising physicochemical properties. CLINICAL RELEVANCE: Sr-PBG-containing LCFVs may offer improved clinical efficacy for caries prevention compared with conventional fluoride varnishes, providing enhanced antibacterial performance and promoting an environment favorable for remineralization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.