Evidence map›Paper›PMID 41114595›Full record

ArticlemBio2025

A broadly conserved fungal chorismate mutase targets the plant shikimate pathway to regulate salicylic acid production and other secondary metabolites.

Dandan Shao, Nathaniel M Westrick, Wende Liu, Oded Yarden, Jun Zhao, Yuri Kimura, Hiroshi Maeda, Damon L Smith, Mehdi Kabbage, Martin B Dickman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dandan ShaoDepartment of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Nathaniel M WestrickValley Laboratory, Connecticut Agricultural Experiment Station, Windsor, Connecticut, USA.
Wende LiuState Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China.
Oded YardenDepartment of Plant Pathology and Microbiology, The R.H. Smith Faculty Agriculture, Food and Environment, The Hebrew University of Jerusalem, Jerusalem, Israel.ORCID 0000-0002-4722-535X
Jun ZhaoDepartment of Horticultural and Plant Protection, Inner Mongolia Agriculture University, Hohhot, Inner Mongolia, China.
Yuri KimuraDepartment of Botany, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Hiroshi MaedaDepartment of Botany, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Damon L SmithDepartment of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Mehdi KabbageDepartment of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, USA.ORCID 0000-0001-6381-9433
Martin B DickmanInstitute for Plant Genomics and Biotechnology, Department of Plant Pathology and Microbiology, Texas A&M University, College Station, Texas, USA.

Funding

U.S. Department of Agriculture 58-3060-8-023U.S. Department of Agriculture Wis04031
6 · The paper itself

Abstract

The molecular dynamics of plant-pathogen interactions are complex, involving a constant defense race between host plants and pathogens. Plants deploy antimicrobial metabolites and physiological responses to inhibit pathogens, while pathogens counteract these defenses using secreted proteinaceous effectors. Chorismate mutases (CMs) are effectors largely studied in biotrophic fungi and nematodes for their ability to hijack the host shikimate pathway by diverting chorismate from salicylic acid (SA) biosynthesis, subsequently undermining SA-mediated defenses against biotrophic infection. While CMs have been primarily linked to biotrophy, we identified a novel bifunctional CM from the broad host range and predominantly necrotrophic pathogen

Indexed as

AscomycotaChorismate MutaseFungal ProteinsPlantsSalicylic AcidSecondary MetabolismShikimic AcidArabidopsisHost-Pathogen InteractionsPlant DiseasesChorismate MutaseFungal ProteinsSalicylic AcidshikimateShikimic Acidnecrotrophic effectorplant-fungal interactionsplant shikimate pathwaysalicylic acid regulationsecreted chorismate mutase

Identifiers

PMID41114595
PMCPMC12607891

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.