Evidence map›Paper›PMID 41114473›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Constructing Dual-Atomic Fe─Fe Sites Nanozyme for Targeted Osteoarthritis Therapy through Mitigating Oxidative Stress and Cartilage Degeneration.

Ting Ying, Qi Wang, Dejian Li, Yao Wang, Pengfang Zhang, Chengqing Yi, Rui Zhu

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ting YingShanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 200092, China.
Qi WangDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201300, China.
Dejian LiDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201300, China.
Yao WangKey Laboratory of Synthetic and Biological Colloids, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi, 214122, China.ORCID https://orcid.org/0000-0001-9578-9128
Pengfang ZhangShandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, Liaocheng University, Liaocheng, 252000, China.
Chengqing YiDepartment of Orthopedics, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201300, China.
Rui ZhuShanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center), School of Medicine, Tongji University, Shanghai, 200092, China.

Funding

Fundamental Research Funds for the Central Universities 22120220635Health Industry Clinical Research Project of Shanghai Health Commission 20224Y0393National clinical key specialty construction project of China Z155080000004National Natural Science Foundation of China 22305101Natural Science Foundation of Jiangsu Province BK20231032New Quality Specialty Clinical Medicine Project of Pudong New Area Health Commission 2024-PWXZ-14Outstanding Leaders Training Program of Pudong Hospital affiliated to Fudan University LX202201Program of Key Medicine of Shanghai Municipal Health Commission 2024ZDXK0031Science and Technology Development Fund of Shanghai Pudong New Area PKJ2023-Y09
6 · The paper itself

Abstract

Osteoarthritis progression is driven by excessive reactive oxygen species (ROS), which causes significant secondary damage to chondrocytes and articular cartilage. Herein, the concept of holding desired dual-site nanozymes is proposed through developing Fe─Fe dimers on nitrogen-doped porous carbon (Fe

Indexed as

Cartilage, ArticularIronOsteoarthritisOxidative StressAnimalsApoptosisChondrocytesHumansReactive Oxygen SpeciesIronReactive Oxygen Speciesdual‐atom sitesFe‐based nanozymeosteoarthritisreactive oxygen speciestargeted antioxidant therapy

Identifiers

PMID41114473
PMCPMC12767132

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.