Evidence map›Paper›PMID 41114464›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

TREM2-Mediated Cholesterol Efflux in Macrophages Inhibits Anti-Tumor Immunity via Limitation of CD4

Yunhan Wang, Weina Yu, Xinxin Wang, Qitai Zhao, Qingyang Lei, Aitian Li, Shasha Liu, Tian Wang, Li Yang, Yi Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yunhan WangBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.ORCID https://orcid.org/0009-0001-8062-2509
Weina YuBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.ORCID https://orcid.org/0009-0000-8951-040X
Xinxin WangBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.ORCID https://orcid.org/0009-0005-9155-2576
Qitai ZhaoBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.ORCID https://orcid.org/0000-0003-4023-2060
Qingyang LeiBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Aitian LiBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.ORCID https://orcid.org/0009-0003-8229-5227
Shasha LiuBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.ORCID https://orcid.org/0000-0003-2441-4024
Tian WangBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.
Li YangBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.ORCID https://orcid.org/0000-0002-9961-1391
Yi ZhangBiotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, China.ORCID https://orcid.org/0000-0001-9861-4681

Funding

Funding for Scientific Research and Innovation Team of The First Affiliated Hospital of Zhengzhou University ZYCXTD2023013National Key R&D Program: Intergovernmental International Science and Technology Innovation Cooperation Project 2021YFE0110600National Key R&D Program: Intergovernmental International Science and Technology Innovation Cooperation Project 2022YFE0141000National Natural Science Foundation of China 82272873National Natural Science Foundation of China 82350121National Natural Science Foundation of China 82573155National Natural Science Foundation of China U24A20734Outstanding Young Talents Project from Henan Province 2523004210210Science and Technology Innovation Team Support Plan from Henan Province 25IRTSTHN039Top Talent Plan from Zhengzhou UniversityYoung and middle-aged Health Science and Technology Innovation Talents in Henan Province LJRC2024012
6 · The paper itself

Abstract

Tumor-associated macrophages (TAMs) predominantly exert functions that facilitate tumor progression. Triggering receptor expressed on myeloid cell 2 (TREM2) is expressed in TAMs, playing a crucial role in mediating the immunosuppressive function of TAMs. The mechanisms by which TREM2

Indexed as

CD4-Positive T-LymphocytesCholesterolKiller Cells, NaturalLung NeoplasmsMacrophagesMembrane GlycoproteinsReceptors, ImmunologicTumor-Associated MacrophagesAnimalsMiceMice, Inbred C57BLMice, KnockoutTumor MicroenvironmentCholesterolMembrane GlycoproteinsReceptors, ImmunologicTrem2 protein, mouseanti‐tumor immunitycholesterolCX3CL1TREM2tumor‐associated macrophagestumor microenvironment

Identifiers

PMID41114464
PMCPMC12850164

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.