Evidence map›Paper›PMID 41114460›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Nanoparticle-Modified Nanofibers Induce Ferroptosis and Stimulate Antitumor Immunity for Melanoma Therapy.

Mingyang Li, Rongrong Li, Baotong Xu, Yuhan Lian, Chenyu Yang, Jingwen Li, Junhao Liang, Linhan Ding, Dongsheng Zhang, Jing Guo and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Mingyang LiDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.
Rongrong LiDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.
Baotong XuDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.
Yuhan LianDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.
Chenyu YangDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.
Jingwen LiDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.
Junhao LiangDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.
Linhan DingDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.
Dongsheng ZhangDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.
Jing GuoDepartment of Dermatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.
Xiao FuDepartment of Stomatology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, No.324 Jingwuweiqi Road, Huaiyin District, Jinan, Shandong Province, 250021, P. R. China.ORCID https://orcid.org/0000-0001-9005-6881

Funding

China Postdoctoral Science Foundation 2022M710852National Natural Science Foundation of China 22202120National Natural Science Foundation of China 82102420Natural Science Foundation of Shandong Province ZR2021MH353Natural Science Foundation of Shandong Province ZR2024QH034Project for Scientific Research Innovation Team of Young Scholars in Colleges and Universities of Shandong Province 2024KJG024Taishan Scholars Foundation of Shandong Province tsqnz20221173
6 · The paper itself

Abstract

Melanoma, a highly aggressive and therapy-resistant cutaneous malignancy, presents formidable clinical challenges owing to its propensity for early metastasis and frequent postoperative recurrence. Here, a nanofiber-based drug delivery system (5F/STFM/R-ES) is developed that synergistically induces ferroptosis and potentiates immunotherapy to inhibit melanoma growth and reduce the risk of metastasis and recurrence. To this end, mesoporous silica nanoparticles encapsulating resiquimod (R848) are surface-coated with Fe/Mn-based metal-polyphenol networks (TFM) to form STFM/R. Subsequently, STFM/R is electrospun into 5-fluorouracil-loaded nanofibers. When applied to the tumor site, 5-fluorouracil and STFM/R are released. Following the degradation of STFM/R, the release of Fe

Indexed as

FerroptosisMelanomaNanofibersNanoparticlesAnimalsCell Line, TumorDrug Delivery SystemsFluorouracilHumansImidazolesImmunotherapyMiceMice, Inbred C57BLFluorouracilImidazolesresiquimodferroptosisimmunotherapymelanomametal‐polyphenol networknanofiber

Identifiers

PMID41114460
PMCPMC12767067

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.