Evidence map›Paper›PMID 41114439›Full record

ArticlePsychological medicine2025

Genetic influences for distinct impulsivity domains are differentially associated with early substance use initiation: Results from the ABCD Study.

Ethan Kinstler, Aaron J Gorelik, Sarah E Paul, Adamya Aggarwal, Emma C Johnson, Melissa A Cyders, Arpana Agrawal, Ryan Bogdan, Alex P Miller

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychological medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Youth Correlates of Genetic Liability to Substance Use Disorders.medRxiv : the preprint server for health sciences · 2025
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Ethan KinstlerDepartment of Psychological & Brain Sciences, https://ror.org/01yc7t268Washington University in Saint Louis, St. Louis, MO, USA.ORCID 0009-0003-5699-7428
Aaron J GorelikDepartment of Psychological & Brain Sciences, https://ror.org/01yc7t268Washington University in Saint Louis, St. Louis, MO, USA.ORCID 0000-0002-2589-1220
Sarah E PaulDepartment of Psychological & Brain Sciences, https://ror.org/01yc7t268Washington University in Saint Louis, St. Louis, MO, USA.ORCID 0000-0003-0320-7907
Adamya AggarwalDepartment of Psychological & Brain Sciences, https://ror.org/01yc7t268Washington University in Saint Louis, St. Louis, MO, USA.ORCID 0009-0009-3239-2188
Emma C JohnsonDepartment of Psychiatry, https://ror.org/01yc7t268Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0003-0394-777X
Melissa A CydersDepartment of Psychology, https://ror.org/05gxnyn08Indiana University Indianapolis, Indianapolis, IN, USA.ORCID 0000-0003-1990-8337
Arpana AgrawalDepartment of Psychiatry, https://ror.org/01yc7t268Washington University School of Medicine, St. Louis, MO, USA.ORCID 0000-0002-0313-793X
Ryan BogdanDepartment of Psychological & Brain Sciences, https://ror.org/01yc7t268Washington University in Saint Louis, St. Louis, MO, USA.ORCID 0000-0002-1430-1045
Alex P MillerDepartment of Psychiatry, https://ror.org/02ets8c94Indiana University School of Medicine, Indianapolis, IN, USA.ORCID 0000-0001-9163-8947

Funding

ABCD-USA Consortium: Coordinating CenterU24DA041147 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI SANDRA A BROWN, TERRY L. JERNIGAN · 2015 to 2026
$54.7M
ABCD-USA Consortium: Data Analysis, Informatics and Resource CenterU24DA041123 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANDERS M DALE · 2015 to 2026
$51.5M
Adolescent Substance Use Initiation: Disentangling neurocognitive risks from consequences using longitudinal and genetically-informed methodsU01DA041120 · NIDA · UNIVERSITY OF MINNESOTA · PI Monica Luciana, Sylia Wilson · 2015 to 2026
$34.5M
ABCD-USA Consortium: Research ProjectU01DA041089 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Joanna Jacobus, Susan F. Tapert · 2015 to 2026
$31.7M
Prospective Research Studies of Maturation (PRISM)- Research ProjectU01DA041134 · NIDA · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI ERIN MCGLADE, PERRY FRANKLIN RENSHAW · 2015 to 2026
$29.2M
ABCD-USA CONSORTIUM: RESEARCH PROJECTU01DA041048 · NIDA · CHILDREN'S HOSPITAL OF LOS ANGELES · PI Megan Marie Herting, ELIZABETH R SOWELL · 2015 to 2026
$28.7M
ABCD-USA Consortium: Research ProjectU01DA041106 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mary M Heitzeg, Chandra Sekhar Sripada · 2015 to 2026
$24.9M
FIU-ABCD: Pathways and Mechanisms to Addiction in the Latino Youth of South FloridaU01DA041156 · NIDA · FLORIDA INTERNATIONAL UNIVERSITY · PI Raul Gonzalez, Angela R Laird · 2015 to 2026
$22.8M
ABCD-USA Consortium: Research ProjectU01DA041148 · NIDA · OREGON HEALTH & SCIENCE UNIVERSITY · PI Damien A Fair, Rebekah S Huber · 2015 to 2026
$22.3M
ABCD-USA: NYC Research ProjectU01DA041174 · NIDA · YALE UNIVERSITY · PI Arielle Ryan Baskin-Sommers, Betty J Casey · 2015 to 2026
$19.7M
Adolescent Brain Cognitive Development (ABCD) Prospective Research in Studies of Maturation (PRISM) ConsortiumU01DA041117 · NIDA · UNIVERSITY OF MARYLAND BALTIMORE · PI LINDA CHANG, THOMAS M ERNST · 2015 to 2026
$19.5M
15/21 ABCD-USA Consortium: Research Project Site at LIBRU01DA050989 · NIDA · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI ROBIN L AUPPERLE, MARTIN P. PAULUS · 2020 to 2026
$14.7M
National Science Foundation Graduate Research Fellowship Program NSF DGE-213989NIAAA NIH HHS F31 AA029934NIAAA NIH HHS F31AA029934NIAAA NIH HHS K01 AA031724NIAAA NIH HHS K01AA031724NIDA NIH HHS K01 DA051759NIDA NIH HHS K01DA051759NIDA NIH HHS R01 DA054750NIDA NIH HHS R01DA054750NIDA NIH HHS U01 DA041022NIDA NIH HHS U01 DA041025NIDA NIH HHS U01 DA041028NIDA NIH HHS U01 DA041048NIDA NIH HHS U01 DA041089NIDA NIH HHS U01 DA041093NIDA NIH HHS U01 DA041106NIDA NIH HHS U01 DA041117NIDA NIH HHS U01 DA041120NIDA NIH HHS U01 DA041134NIDA NIH HHS U01 DA041148NIDA NIH HHS U01 DA041156NIDA NIH HHS U01 DA041174NIDA NIH HHS U01 DA050987NIDA NIH HHS U01 DA050988NIDA NIH HHS U01 DA050989NIDA NIH HHS U01 DA051016NIDA NIH HHS U01 DA051018NIDA NIH HHS U01 DA051037NIDA NIH HHS U01 DA051038NIDA NIH HHS U01 DA051039NIDA NIH HHS U24 DA041123NIDA NIH HHS U24 DA041147
6 · The paper itself

Abstract

backgroundImpulsivity is among the strongest correlates of substance involvement (i.e. a broad continuum of substance-related behaviors), and distinct domains (e.g. sensation seeking [SS] and urgency) are differentially correlated, phenotypically and genetically, with unique substance involvement stages. Examining whether polygenic influences for distinct impulsivity domains are differentially predictive of early substance use initiation - a major risk factor for later problematic use - may improve our understanding of the role of impulsivity in addiction etiology.

methodsData collected from participants of genetically inferred European ancestry enrolled in the Adolescent Brain Cognitive Development Study

resultsSS-PGS was significantly associated with any substance and alcohol use initiation (odds ratio [ORs] > 1.10,

conclusionsGenetic influences for distinct impulsivity domains have differential associations with early substance use initiation, with SS showing the most robust associations, highlighting valuable etiological insight into the earliest stages of substance involvement that may be leveraged to improve prevention and intervention strategies.

Indexed as

Adolescent BehaviorImpulsive BehaviorMultifactorial InheritanceSubstance-Related DisordersAdolescentChildFemaleHumansMaleRisk Factorschildhoodearly adolescenceimpulsivityparallel mediationpolygenic scoressubstance use initiation

Identifiers

PMID41114439
PMCPMC12551585

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.