Evidence map›Paper›PMID 41114396›Full record

ArticleIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine2025

Differential Mortality Benefit of Beta-blockers in Septic Shock: A Subgroup Meta-analysis.

Habib Mr Karim, Ankur Khandelwal, Dalim K Baidya, Rajathadri H Ravikumar

Abstract read
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Article in Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Habib Mr KarimDepartment of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences, Guwahati, Assam, India.ORCID https://orcid.org/0000-0002-6632-0491
Ankur KhandelwalDepartment of Anaesthesiology, Critical Care and Pain Medicine, All India Institute of Medical Sciences, Guwahati, Assam, India.ORCID https://orcid.org/0000-0002-7915-9158
Dalim K BaidyaDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0001-7811-7039
Rajathadri H RavikumarDepartment of Anaesthesiology, Pain Medicine and Critical Care, All India Institute of Medical Sciences, New Delhi, India.ORCID https://orcid.org/0000-0002-9295-5933

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Tachycardia in septic shock is a typical physiological response driven by sympathetic activation and vasopressor use. While initially compensatory, excessive heart rates (HRs) can compromise myocardial efficiency and lead to worse outcomes. Targeted HR control has been proposed to mitigate these effects, although the evidence remains inconclusive. Objective: To evaluate drug-specific effects of HR control agents on 28-day all-cause mortality in patients with septic shock requiring vasopressor support. Methods: A subgroup meta-analysis and meta-regression were performed using randomized controlled trials (RCTs) included in a recent systematic review. Relative risk (RR) estimates and heterogeneity ( Results: Esmolol ( Conclusion: Esmolol appears beneficial, while Ivabradine and Landiolol show no clear mortality advantage. Further head-to-head trials are warranted. How to cite this article: Karim HMR, Khandelwal A, Baidya DK, Ravikumar RH. Differential Mortality Benefit of Beta-blockers in Septic Shock: A Subgroup Meta-analysis. Indian J Crit Care Med 2025;29(8):704-707.

Indexed as

28-day mortalityEsmololIvabradineLandiololSeptic shockTachycardia

Identifiers

PMID41114396
PMCPMC12532242

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.