ArticleJournal of pain research2025
Acupuncture Modalities Differentially Modulate Pain and Joint Damage in a Rat Model of Knee Osteoarthritis.
Article in Journal of pain research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Efficacy of laser acupuncture for patients with knee osteoarthritis: a systematic review and meta-analysis of randomized controlled trials.Lasers in medical science · 2026Pooled it
- Therapeutic effect of modified meridian-guided acupoint pressing on lumbar facet joint osteoarthritis: an integrated microbiomics and metabolomics analysis.Frontiers in medicine · 2026Article
- Efficacy and Spinal Noradrenergic Mechanisms of Contralateral Melittin Acupuncture Against Paclitaxel-Induced Peripheral Neuropathic Pain in Rats.Journal of pain research · 2026Article
- From concept to practice: intra-articular photobiomodulation for knee osteoarthritis.Frontiers in immunology · 2026Review
- Comment on "Acupuncture Modalities Differentially Modulate Pain and Joint Damage in a Rat Model of Knee Osteoarthritis" [Letter].Journal of pain research · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Osteoarthritis (OA) is a leading cause of chronic pain and disability worldwide. Acupuncture-based therapies, including Electroacupuncture (EA), bee venom acupuncture (BVA), and laser acupuncture (LA), have shown individual efficacy in OA treatment, yet direct comparisons under standardized conditions remain lacking. Objective: This study compared the therapeutic effects of EA, BVA, and LA in a monosodium iodoacetate (MIA)- induced OA in a rat model using consistent treatment protocols and evaluation metrics. Methods: Forty-eight male Sprague-Dawley rats were randomly assigned to six groups: control, OA, manual acupuncture (MA), EA, BVA, and LA. All treatments were administered at acupoint GB34 three times per week for four weeks, beginning one week after MIA induction. Pain behavior was assessed weekly via paw withdrawal threshold testing. Post-treatment analyses included micro-computed tomography (micro-CT) imaging and histological evaluation. Results: EA and LA significantly alleviated pain behaviors beginning at Weeks 2-3 and demonstrated superior joint preservation and cartilage integrity by Week 4 (p < 0.001 vs OA). BVA produced early analgesic effects and moderate structural protection, MA showed partial therapeutic benefits. EA and LA yielded the most consistent and comprehensive improvements among the treatments. Conclusion: LA and EA at GB34 could potentially improve pain hypersensitivity, bone structure, and cartilage degradation. Our study provides a direct comparison of LA, EA, MA, and BVA under standardized conditions and may inform patients and healthcare practitioners considering acupuncture therapy options for OA management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.