ArticleFrontiers in oncology2025
Treatment efficacy of first-line immunotherapy in advanced esophageal small cell carcinoma: A real-world retrospective study.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Small cell carcinoma of the esophagus (SCCE) is a rare and highly aggressive malignancy characterized by early metastatic propensity. Traditional chemotherapy has a poor curative effect and a short survival period Recent evidence demonstrates that combining immune checkpoint inhibitors (ICIs) with chemotherapy significantly improves therapeutic outcomes in both advanced esophageal carcinoma and small cell lung cancer. This study aims to evaluate the efficacy of first-line ICIs combined with chemotherapy in patients with advanced SCCE. Patients and methods: This single-center retrospective study analyzed 31 patients with advanced SCCE who initiated first-line systemic therapy at our institution between January 2021 and August 2024. All patients received physician-determined treatment regimens. The study aimed to evaluate the efficacy of first-line immunotherapy combined with chemotherapy in advanced SCCE. Results: Median progression-free survival (PFS) was significantly longer in the immunotherapy group (9.3 months; 95% CI 6.3-12.3) compared to the non-immunotherapy group (5.4 months; 95% CI 3.5-7.3; Conclusion: Esophageal small cell carcinoma remains a highly aggressive malignancy with poor prognosis in advanced stages. This retrospective real-world study suggests that first-line immunotherapy combined with chemotherapy may significantly improve progression-free survival in patients with advanced SCCE compared to chemotherapy alone.
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