ArticleACS omega2025
LCI Engineering for Improved Polystyrene Binding: The Impact of Aromatic Amino Acid Substitutions.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Toroidal Dipole-Dominated High-Performance Optical Sensors via Nanoimprinted Tetramer Architectures.Nanophotonics (Berlin, Germany) · 2026Article
- Toward Material-Specific Peptides From in Silico Guided Peptide Engineering to Target PET in the Presence of PS.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Polystyrene (PS) is a widely used synthetic polymer with applications in biosensing, medical devices, and packaging. PS often requires surface modifications to enhance biocompatibility, adhesion, and chemical functionality. Material-binding peptides (MBPs) provide a biobased and scalable approach for PS functionalization. Therefore, optimizing their binding properties can ensure stable and efficient binding under industrial application conditions. In this study, we systematically explored how aromatic amino acid substitutions (His, Phe, Trp, and Tyr) affect the PS binding ability of the MBP named liquid chromatography peak I (LCI). A total of 178 aromatic amino acid substitutions were evaluated across all 47 positions of LCI, resulting in the identification of 56 substitutions across 32 positions that improved the PS binding. Among these, the LCI-L4H variant showed the most impoved binding to PS and was further biophysically characterized to determine the surface coverage by surface plasmon resonance (SPR). SPR analysis showed that L4H increased the coating density from 7.90 to 9.18 pmol/cm
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Registered trials
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