Visible-Light-Driven Photocatalyst-Free Multicomponent Reactions: Green Synthesis of Tetraketones as Potent Antiviral Agents through Virtual Screening, Molecular Docking, and MD Simulations.

Swadhin Swaraj Acharya, Ananya Roul, Jarmani Dansana, Alisha Rani Tripathy, Abhishikta Gadtya, Biswa Ranjan Meher, Bibhuti Bhusan Parida

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Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

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1 citing paper in PubMed.

Multicomponent synthesis of 2RSC advances · 2026
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5 · Who and what money

Authors and funding

7 authors.

Swadhin Swaraj AcharyaOrganic Synthesis Laboratory, P. G. Department of Chemistry, Berhampur University, Bhanja Bihar, Odisha 760007, India.

Ananya RoulOrganic Synthesis Laboratory, P. G. Department of Chemistry, Berhampur University, Bhanja Bihar, Odisha 760007, India.

Jarmani DansanaComputational Biology and Bioinformatics Laboratory, P. G. Department of Botany, Berhampur University, Bhanja Bihar, Odisha 760007, India.

Alisha Rani TripathyOrganic Synthesis Laboratory, P. G. Department of Chemistry, Berhampur University, Bhanja Bihar, Odisha 760007, India.

Abhishikta GadtyaComputational Biology and Bioinformatics Laboratory, P. G. Department of Botany, Berhampur University, Bhanja Bihar, Odisha 760007, India.

Biswa Ranjan MeherComputational Biology and Bioinformatics Laboratory, P. G. Department of Botany, Berhampur University, Bhanja Bihar, Odisha 760007, India.ORCID https://orcid.org/0000-0003-0519-9074

Bibhuti Bhusan ParidaOrganic Synthesis Laboratory, P. G. Department of Chemistry, Berhampur University, Bhanja Bihar, Odisha 760007, India.ORCID https://orcid.org/0000-0001-8623-0429

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Herein, we report a photocatalyst (PC)-free, visible-light (30 W LED)-driven green and sustainable synthesis of a series of functionalized tetraketones by a one-pot multicomponent reaction at room temperature. The ethanol-mediated reaction of variably substituted aromatic/heteroaromatic, aliphatic aldehydes, and dimedone furnished the biologically relevant tetraketones in very good yields (72-92%) in 10 min to 5 h. The key advantages of the current process include its environmentally benign aspect, operational simplicity, easy isolation of the products, high yields, PC- and metal-free aspects, employment of visible light as a green and sustainable energy source, and gram-scale synthesis. The synthesized tetraketones are further subjected to

Identifiers

PMID41114238

DOI10.1021/acsomega.4c10660

PMCPMC12529182

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