ReviewACS omega2025
Recent Progress in the Synthesis, Functionalization, and Biological Outlook of Pyrimidines.
Review in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Synthesis and Characterization of New Functionalized Pyrimidine (Hetero)Cyclic Molecular Hybrids as Chiral Heterocyclic Amino Acid Derivatives.Molecules (Basel, Switzerland) · 2026Article
- Benzimidazole motifs in drug discovery: sustainable synthetic strategies and emerging biological applications.RSC advances · 2026Review
- Heterocycles in Medicinal Chemistry III.Molecules (Basel, Switzerland) · 2026Article
- Thienopyrimidine scaffolds as promising antimicrobial agents: synthesis, biological evaluation, DFT analysis and molecular docking.RSC advances · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyrimidine-containing heterocyclic molecules are highly important in medicinal chemistry because of their versatile biological activities and their potential for structural modification. These scaffolds have consistently attracted the attention of chemists and biologists alike and serve as key building blocks in the design and development of bioactive compounds. Recent advances in pyrimidine chemistryincluding novel synthetic methodologies, named reactions, catalytic strategies, and functionalization techniqueshave further expanded their applicability. The biological importance of pyrimidine derivatives has been instrumental in the development of several commercially available drugs in recent years. Given the ongoing global research in this area, there is a clear need to review and highlight recent developments in a systematic manner. This review not only provides insights into current trends but also serves as a valuable resource for researchers in the pharmaceutical industry and academic institutions engaged in early-stage drug discovery efforts.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.