ArticleACS omega2025
Quantitative Lateral Flow Assay for Meropenem Determination: A Proof-of-Concept Study.
Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Therapeutic drug monitoring (TDM) is essential for optimizing antibiotic dosing, particularly in critically ill patients. However, conventional methods, such as LC/MS, have long turnaround times, limiting timely dose adjustment. We developed a novel competitive lateral flow assay (LFA) format with dual test lines previously validated for vancomycin and adapted it for Meropenem quantification. Using BlaR-CTD, a beta-lactam receptor protein, in place of an antibody and biotinylated BSA-Meropenem conjugated to gold nanoparticles, the LFA produced a concentration-dependent change in test line intensities. A custom image analysis algorithm showed strong correlation with Meropenem concentrations (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.