ReviewACS omega2025
Decoding Protein Corona Through Synchrotron-Based Small-Angle X‑Ray Scattering.
Review in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Fractionation-Free Protein Corona Quantification Through Synchrotron-Based Small-Angle X-ray Scattering.Small methods · 2026Article
- The protein corona at the nano-bio interface: the need for standardized methodology and opportunities for neurodegenerative disease intervention.RSC advances · 2026Review
- Probing Membrane Structure of Lipid Nanomedicines Using Solution Small-Angle X-Ray Scattering: Applications and Prospects.Membranes · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nanoparticles (NPs) in biological environments rapidly become coated with a dynamic biomolecular layer known as the protein corona (PC), significantly influencing their biological identity and functionality. Traditional methods used to characterize the PC often disrupt its native state, limiting accurate insights into its true structural and compositional complexity. Synchrotron-based small-angle X-ray scattering (SAXS) provides a powerful alternative, enabling nondestructive, label-free, and in-solution analysis of the PC under physiologically relevant conditions. This minireview critically examines recent advancements in applying SAXS to decode the PC, highlighting methodological developments and exemplary studies demonstrating SAXS's unique ability to resolve interactions at the nano-bio interface. By discussing novel analytical frameworks, such as integrating SAXS with complementary techniques like small-angle neutron scattering (SANS) and cryo-transmission electron microscopy (cryo-TEM), we provide a comprehensive overview on the structural and thermodynamic features of the PC. Furthermore, we outline future opportunities including time-resolved SAXS to elucidate the kinetics of corona formation and the establishment of standardized protocols to enhance reproducibility and reliability. Ultimately, this review positions SAXS as an indispensable tool for advancing our understanding of nanoparticle-protein interactions and fostering innovation in nanomedicine.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.