Evidence map›Paper›PMID 41114156›Full record

ArticleACS omega2025

Gold Mono- and Bis-N-heterocyclic Carbenes Based on mRNA cap0.

Giulia Francescato, Giulia Orsini, Ana Petronilho

Abstract read
In one paragraph

Article in ACS omega, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Giulia FrancescatoInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa. Av. da República, 2780-157 Oeiras, Portugal.
Giulia OrsiniInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa. Av. da República, 2780-157 Oeiras, Portugal.
Ana PetronilhoInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa. Av. da República, 2780-157 Oeiras, Portugal.ORCID https://orcid.org/0000-0002-3296-1522

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eukaryotic mRNA contains a cap structure that consists of a methylated guanosine (mRNA cap0) connected to the first transcribed nucleotide by an unusual 5'-5'-triphosphate bridge. Herein, we describe the synthesis of gold mono- and bis-N-heterocyclic carbenes derived from 7-methylguanosine at room temperature. The compounds can be synthesized directly from 7-methylguanosine, and the synthesis does not require the protection of the hydroxyl groups of the ribose to be effective. The synthesis was also performed successfully with the acetate protected nucleoside, but deprotection of the sugar was not effective. The compounds are stable under air, both in the solid state and in solution. Gold monocarbene

Identifiers

PMID41114156
PMCPMC12529129

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.