ReviewJournal of diabetes and metabolic disorders2025
Adjunctive melatonin in periodontal therapy for type 2 diabetic patients: Systematic review and Meta-Analysis.
Review in Journal of diabetes and metabolic disorders, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Efficacy of antioxidants supplementation as an adjunct to non-surgical periodontal therapy: an umbrella meta-analysis.Odontology · 2026Review
- Effect of Melatonin Gel as an Adjunct to Non-Surgical Periodontal Therapy: A Systematic Review of Randomized Controlled Trials.Journal of clinical medicine · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Melatonin has anti-inflammatory and antioxidant properties relevant to periodontal therapy. However, its effectiveness as an adjunct in patients with type 2 diabetes and periodontitis remains uncertain. This meta-analysis evaluated its clinical impact in this population. Materials and methods: We searched PubMed, Embase, and the Cochrane Library through June 2025 for studies comparing adjunctive melatonin plus scaling and root planing (SRP) versus SRP alone or placebo in patients with type 2 diabetes and periodontitis. Primary outcomes were probing depth (PD), clinical attachment level (CAL), and bleeding on probing (BOP). Secondary outcome: plaque index (PI). Meta-analyses used a random-effects model (Review Manager 5.4), and risk of bias was assessed with the Cochrane RoB 2 tool. Results: Of 79 records, 4 studies (269 participants) were included. Adjunctive melatonin significantly improved PD (mean difference [MD]: -1.38 mm; 95% CI: -2.28 to - 0.47; Conclusion: Adjunctive melatonin improves clinical periodontal parameters and reduces inflammation in patients with type 2 diabetes and periodontitis. These findings suggest melatonin may serve as a biologically plausible and well-tolerated adjunct, though current evidence remains limited and should be interpreted with caution. Further high-quality trials are needed to confirm these outcomes.
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Registered trials
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